{"intvolume":"       311","author":[{"last_name":"Xu","first_name":"Jian","full_name":"Xu, Jian"},{"last_name":"Hofhuis","full_name":"Hofhuis, Hugo","first_name":"Hugo"},{"first_name":"Renze","full_name":"Heidstra, Renze","last_name":"Heidstra"},{"full_name":"Sauer, Michael","first_name":"Michael","last_name":"Sauer"},{"first_name":"Jirí","full_name":"Jirí Friml","last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ben","full_name":"Scheres, Ben","last_name":"Scheres"}],"month":"01","publication_status":"published","quality_controlled":0,"publisher":"American Association for the Advancement of Science","publist_id":"3695","issue":"5759","date_created":"2018-12-11T12:00:50Z","page":"385 - 388","abstract":[{"text":"Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin-a cell-fate-instructive plant hormone-in root tips, and we demonstrate that resulting cell-fate changes require the PLETHORA, SHORTROOT, and SCARECROW transcription factors. These transcription factors regulate the expression and polar position of PIN auxin efflux-facilitating membrane proteins to reconstitute auxin transport in renewed root tips. Thus, a regeneration mechanism using embryonic root stem-cell patterning factors first responds to and subsequently stabilizes a new hormone distribution.","lang":"eng"}],"date_published":"2006-01-20T00:00:00Z","date_updated":"2021-01-12T07:40:25Z","title":"A molecular framework for plant regeneration","doi":"10.1126/science.1121790","extern":1,"volume":311,"status":"public","year":"2006","_id":"3008","publication":"Science","type":"journal_article","citation":{"ieee":"J. Xu, H. Hofhuis, R. Heidstra, M. Sauer, J. Friml, and B. Scheres, “A molecular framework for plant regeneration,” <i>Science</i>, vol. 311, no. 5759. American Association for the Advancement of Science, pp. 385–388, 2006.","apa":"Xu, J., Hofhuis, H., Heidstra, R., Sauer, M., Friml, J., &#38; Scheres, B. (2006). A molecular framework for plant regeneration. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1121790\">https://doi.org/10.1126/science.1121790</a>","ista":"Xu J, Hofhuis H, Heidstra R, Sauer M, Friml J, Scheres B. 2006. A molecular framework for plant regeneration. Science. 311(5759), 385–388.","chicago":"Xu, Jian, Hugo Hofhuis, Renze Heidstra, Michael Sauer, Jiří Friml, and Ben Scheres. “A Molecular Framework for Plant Regeneration.” <i>Science</i>. American Association for the Advancement of Science, 2006. <a href=\"https://doi.org/10.1126/science.1121790\">https://doi.org/10.1126/science.1121790</a>.","short":"J. Xu, H. Hofhuis, R. Heidstra, M. Sauer, J. Friml, B. Scheres, Science 311 (2006) 385–388.","ama":"Xu J, Hofhuis H, Heidstra R, Sauer M, Friml J, Scheres B. A molecular framework for plant regeneration. <i>Science</i>. 2006;311(5759):385-388. doi:<a href=\"https://doi.org/10.1126/science.1121790\">10.1126/science.1121790</a>","mla":"Xu, Jian, et al. “A Molecular Framework for Plant Regeneration.” <i>Science</i>, vol. 311, no. 5759, American Association for the Advancement of Science, 2006, pp. 385–88, doi:<a href=\"https://doi.org/10.1126/science.1121790\">10.1126/science.1121790</a>."},"day":"20"}