Interactions of PIN and PGP auxin transport mechanisms Biochemical Society Transactions Bandyopadhyay, Anindita Blakeslee, Joshua Lee, Ok Ran Mravec, Jozef Sauer, Michael Titapiwatanakun, Boosaree Makam, Srinivas N Bouchard, Rodolphe Geisler, Markus Martinoia, Enrico Jirí Friml ; https://orcid.org/0000-0002-8302-7596 Peer, Wendy A Murphy, Angus S Polarized transport of the plant hormone auxin influences multiple growth processes in plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP (P-glycoprotein) ABC transporters (ATP-binding-cassette transporters), PIN (pin-formed) subfamily of major facilitator proteins and members of AUX/LAX families have been shown to independently transport auxin both in planta and in heterologous systems. However, PIN- and PGP-mediated transport in heterologous systems exhibits decreased substrate specificity and inhibitor-sensitivity compared with what is seen in plants and plant cells. To determine whether PIN-PGP interactions enhance transport specificity, we analysed interactions of the representative auxin-transporting PGPs with PIN1 and AUX1 in planta and in heterologous systems. Here, we provide evidence that PINs and PGPs interact and function both independently and co-ordinately to control polar auxin transport and impart transport specificity and directionality. These interactions take place in protein complexes stabilized by PGPs in detergent-resistant microdomains. Portland Press 2007 info:eu-repo/semantics/conferenceObject doc-type:conferenceObject text http://purl.org/coar/resource_type/c_5794 https://research-explorer.ista.ac.at/record/3021 Bandyopadhyay A, Blakeslee J, Lee O, et al. Interactions of PIN and PGP auxin transport mechanisms. In: Vol 35. Portland Press; 2007:137-141. doi:<a href="https://doi.org/10.1042/BST0350137">10.1042/BST0350137</a> info:eu-repo/semantics/altIdentifier/doi/10.1042/BST0350137 info:eu-repo/semantics/closedAccess