---
_id: '3036'
abstract:
- lang: eng
  text: Plants exhibit an exceptional adaptability to different environmental conditions.
    To a large extent, this adaptability depends on their ability to initiate and
    form new organs throughout their entire postembryonic life. Plant shoot and root
    systems unceasingly branch and form axillary shoots or lateral roots, respectively.
    The first event in the formation of a new organ is specification of founder cells.
    Several plant hormones, prominent among them auxin, have been implicated in the
    acquisition of founder cell identity by differentiated cells, but the mechanisms
    underlying this process are largely elusive. Here, we show that auxin and its
    local accumulation in root pericycle cells is a necessary and sufficient signal
    to respecify these cells into lateral root founder cells. Analysis of the alf4-1
    mutant suggests that specification of founder cells and the subsequent activation
    of cell division leading to primordium formation represent two genetically separable
    events. Time-lapse experiments show that the activation of an auxin response is
    the earliest detectable event in founder cell specification. Accordingly, local
    activation of auxin response correlates absolutely with the acquisition of founder
    cell identity and precedes the actual formation of a lateral root primordium through
    patterned cell division. Local production and subsequent accumulation of auxin
    in single pericycle cells induced by Cre-Lox-based activation of auxin synthesis
    converts them into founder cells. Thus, auxin is the local instructive signal
    that is sufficient for acquisition of founder cell identity and can be considered
    a morphogenetic trigger in postembryonic plant organogenesis.
author:
- first_name: Joseph
  full_name: Dubrovsky, Joseph G
  last_name: Dubrovsky
- first_name: Michael
  full_name: Sauer, Michael
  last_name: Sauer
- first_name: Selene
  full_name: Napsucialy-Mendivil, Selene
  last_name: Napsucialy Mendivil
- first_name: Maria
  full_name: Ivanchenko, Maria G
  last_name: Ivanchenko
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Svetlana
  full_name: Shishkova, Svetlana
  last_name: Shishkova
- first_name: John
  full_name: Celenza, John
  last_name: Celenza
- first_name: Eva
  full_name: Eva Benková
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Dubrovsky J, Sauer M, Napsucialy Mendivil S, et al. Auxin acts as a local morphogenetic
    trigger to specify lateral root founder cells. <i>PNAS</i>. 2008;105(25):8790-8794.
    doi:<a href="https://doi.org/10.1073/pnas.0712307105">10.1073/pnas.0712307105</a>
  apa: Dubrovsky, J., Sauer, M., Napsucialy Mendivil, S., Ivanchenko, M., Friml, J.,
    Shishkova, S., … Benková, E. (2008). Auxin acts as a local morphogenetic trigger
    to specify lateral root founder cells. <i>PNAS</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.0712307105">https://doi.org/10.1073/pnas.0712307105</a>
  chicago: Dubrovsky, Joseph, Michael Sauer, Selene Napsucialy Mendivil, Maria Ivanchenko,
    Jiří Friml, Svetlana Shishkova, John Celenza, and Eva Benková. “Auxin Acts as
    a Local Morphogenetic Trigger to Specify Lateral Root Founder Cells.” <i>PNAS</i>.
    National Academy of Sciences, 2008. <a href="https://doi.org/10.1073/pnas.0712307105">https://doi.org/10.1073/pnas.0712307105</a>.
  ieee: J. Dubrovsky <i>et al.</i>, “Auxin acts as a local morphogenetic trigger to
    specify lateral root founder cells,” <i>PNAS</i>, vol. 105, no. 25. National Academy
    of Sciences, pp. 8790–8794, 2008.
  ista: Dubrovsky J, Sauer M, Napsucialy Mendivil S, Ivanchenko M, Friml J, Shishkova
    S, Celenza J, Benková E. 2008. Auxin acts as a local morphogenetic trigger to
    specify lateral root founder cells. PNAS. 105(25), 8790–8794.
  mla: Dubrovsky, Joseph, et al. “Auxin Acts as a Local Morphogenetic Trigger to Specify
    Lateral Root Founder Cells.” <i>PNAS</i>, vol. 105, no. 25, National Academy of
    Sciences, 2008, pp. 8790–94, doi:<a href="https://doi.org/10.1073/pnas.0712307105">10.1073/pnas.0712307105</a>.
  short: J. Dubrovsky, M. Sauer, S. Napsucialy Mendivil, M. Ivanchenko, J. Friml,
    S. Shishkova, J. Celenza, E. Benková, PNAS 105 (2008) 8790–8794.
date_created: 2018-12-11T12:00:59Z
date_published: 2008-06-24T00:00:00Z
date_updated: 2021-01-12T07:40:36Z
day: '24'
doi: 10.1073/pnas.0712307105
extern: 1
fulldoi: https://doi.org/10.1073/pnas.0712307105
intvolume: '       105'
issue: '25'
month: '06'
page: 8790 - 8794
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3666'
quality_controlled: 0
status: public
title: Auxin acts as a local morphogenetic trigger to specify lateral root founder
  cells
type: journal_article
volume: 105
year: '2008'
...