---
_id: '3050'
abstract:
- lang: eng
  text: 'Plant development is governed by signaling molecules called phytohormones.
    Typically, in certain developmental processes more than 1 hormone is implicated
    and, thus, coordination of their overlapping activities is crucial for correct
    plant development. However, molecular mechanisms underlying the hormonal crosstalk
    are only poorly understood. Multiple hormones including cytokinin and auxin have
    been implicated in the regulation of root development. Here we dissect the roles
    of cytokinin in modulating growth of the primary root. We show that cytokinin
    effect on root elongation occurs through ethylene signaling whereas cytokinin
    effect on the root meristem size involves ethylene-independent modulation of transport-dependent
    asymmetric auxin distribution. Exogenous or endogenous modification of cytokinin
    levels and cytokinin signaling lead to specific changes in transcription of several
    auxin efflux carrier genes from the PIN family having a direct impact on auxin
    efflux from cultured cells and on auxin distribution in the root apex. We propose
    a novel model for cytokinin action in regulating root growth: Cytokinin influences
    cell-to-cell auxin transport by modification of expression of several auxin transport
    components and thus modulates auxin distribution important for regulation of activity
    and size of the root meristem.'
author:
- first_name: Kamil
  full_name: Růžička, Kamil
  last_name: Růžička
- first_name: Mária
  full_name: Šimášková, Mária
  last_name: Šimášková
- first_name: Jérôme
  full_name: Duclercq, Jérôme
  last_name: Duclercq
- first_name: Jan
  full_name: Petrášek, Jan
  last_name: Petrášek
- first_name: Eva
  full_name: Zažímalová, Eva
  last_name: Zažímalová
- first_name: Sibu
  full_name: Sibu Simon
  id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
  last_name: Simon
  orcid: 0000-0002-1998-6741
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Marc
  full_name: Van Montagu, Marc C
  last_name: Van Montagu
- first_name: Eva
  full_name: Eva Benková
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Růžička K, Šimášková M, Duclercq J, et al. Cytokinin regulates root meristem
    activity via modulation of the polar auxin transport. <i>PNAS</i>. 2009;106(11):4284-4289.
    doi:<a href="https://doi.org/10.1073/pnas.0900060106">10.1073/pnas.0900060106</a>
  apa: Růžička, K., Šimášková, M., Duclercq, J., Petrášek, J., Zažímalová, E., Simon,
    S., … Benková, E. (2009). Cytokinin regulates root meristem activity via modulation
    of the polar auxin transport. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.0900060106">https://doi.org/10.1073/pnas.0900060106</a>
  chicago: Růžička, Kamil, Mária Šimášková, Jérôme Duclercq, Jan Petrášek, Eva Zažímalová,
    Sibu Simon, Jiří Friml, Marc Van Montagu, and Eva Benková. “Cytokinin Regulates
    Root Meristem Activity via Modulation of the Polar Auxin Transport.” <i>PNAS</i>.
    National Academy of Sciences, 2009. <a href="https://doi.org/10.1073/pnas.0900060106">https://doi.org/10.1073/pnas.0900060106</a>.
  ieee: K. Růžička <i>et al.</i>, “Cytokinin regulates root meristem activity via
    modulation of the polar auxin transport,” <i>PNAS</i>, vol. 106, no. 11. National
    Academy of Sciences, pp. 4284–4289, 2009.
  ista: Růžička K, Šimášková M, Duclercq J, Petrášek J, Zažímalová E, Simon S, Friml
    J, Van Montagu M, Benková E. 2009. Cytokinin regulates root meristem activity
    via modulation of the polar auxin transport. PNAS. 106(11), 4284–4289.
  mla: Růžička, Kamil, et al. “Cytokinin Regulates Root Meristem Activity via Modulation
    of the Polar Auxin Transport.” <i>PNAS</i>, vol. 106, no. 11, National Academy
    of Sciences, 2009, pp. 4284–89, doi:<a href="https://doi.org/10.1073/pnas.0900060106">10.1073/pnas.0900060106</a>.
  short: K. Růžička, M. Šimášková, J. Duclercq, J. Petrášek, E. Zažímalová, S. Simon,
    J. Friml, M. Van Montagu, E. Benková, PNAS 106 (2009) 4284–4289.
date_created: 2018-12-11T12:01:04Z
date_published: 2009-03-17T00:00:00Z
date_updated: 2021-01-12T07:40:42Z
day: '17'
doi: 10.1073/pnas.0900060106
extern: 1
intvolume: '       106'
issue: '11'
month: '03'
page: 4284 - 4289
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3652'
quality_controlled: 0
status: public
title: Cytokinin regulates root meristem activity via modulation of the polar auxin
  transport
type: journal_article
volume: 106
year: '2009'
...