--- _id: '3050' abstract: - lang: eng text: 'Plant development is governed by signaling molecules called phytohormones. Typically, in certain developmental processes more than 1 hormone is implicated and, thus, coordination of their overlapping activities is crucial for correct plant development. However, molecular mechanisms underlying the hormonal crosstalk are only poorly understood. Multiple hormones including cytokinin and auxin have been implicated in the regulation of root development. Here we dissect the roles of cytokinin in modulating growth of the primary root. We show that cytokinin effect on root elongation occurs through ethylene signaling whereas cytokinin effect on the root meristem size involves ethylene-independent modulation of transport-dependent asymmetric auxin distribution. Exogenous or endogenous modification of cytokinin levels and cytokinin signaling lead to specific changes in transcription of several auxin efflux carrier genes from the PIN family having a direct impact on auxin efflux from cultured cells and on auxin distribution in the root apex. We propose a novel model for cytokinin action in regulating root growth: Cytokinin influences cell-to-cell auxin transport by modification of expression of several auxin transport components and thus modulates auxin distribution important for regulation of activity and size of the root meristem.' author: - first_name: Kamil full_name: Růžička, Kamil last_name: Růžička - first_name: Mária full_name: Šimášková, Mária last_name: Šimášková - first_name: Jérôme full_name: Duclercq, Jérôme last_name: Duclercq - first_name: Jan full_name: Petrášek, Jan last_name: Petrášek - first_name: Eva full_name: Zažímalová, Eva last_name: Zažímalová - first_name: Sibu full_name: Sibu Simon id: 4542EF9A-F248-11E8-B48F-1D18A9856A87 last_name: Simon orcid: 0000-0002-1998-6741 - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Marc full_name: Van Montagu, Marc C last_name: Van Montagu - first_name: Eva full_name: Eva Benková id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 citation: ama: Růžička K, Šimášková M, Duclercq J, et al. Cytokinin regulates root meristem activity via modulation of the polar auxin transport. PNAS. 2009;106(11):4284-4289. doi:10.1073/pnas.0900060106 apa: Růžička, K., Šimášková, M., Duclercq, J., Petrášek, J., Zažímalová, E., Simon, S., … Benková, E. (2009). Cytokinin regulates root meristem activity via modulation of the polar auxin transport. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0900060106 chicago: Růžička, Kamil, Mária Šimášková, Jérôme Duclercq, Jan Petrášek, Eva Zažímalová, Sibu Simon, Jiří Friml, Marc Van Montagu, and Eva Benková. “Cytokinin Regulates Root Meristem Activity via Modulation of the Polar Auxin Transport.” PNAS. National Academy of Sciences, 2009. https://doi.org/10.1073/pnas.0900060106. ieee: K. Růžička et al., “Cytokinin regulates root meristem activity via modulation of the polar auxin transport,” PNAS, vol. 106, no. 11. National Academy of Sciences, pp. 4284–4289, 2009. ista: Růžička K, Šimášková M, Duclercq J, Petrášek J, Zažímalová E, Simon S, Friml J, Van Montagu M, Benková E. 2009. Cytokinin regulates root meristem activity via modulation of the polar auxin transport. PNAS. 106(11), 4284–4289. mla: Růžička, Kamil, et al. “Cytokinin Regulates Root Meristem Activity via Modulation of the Polar Auxin Transport.” PNAS, vol. 106, no. 11, National Academy of Sciences, 2009, pp. 4284–89, doi:10.1073/pnas.0900060106. short: K. Růžička, M. Šimášková, J. Duclercq, J. Petrášek, E. Zažímalová, S. Simon, J. Friml, M. Van Montagu, E. Benková, PNAS 106 (2009) 4284–4289. date_created: 2018-12-11T12:01:04Z date_published: 2009-03-17T00:00:00Z date_updated: 2021-01-12T07:40:42Z day: '17' doi: 10.1073/pnas.0900060106 extern: 1 intvolume: ' 106' issue: '11' month: '03' page: 4284 - 4289 publication: PNAS publication_status: published publisher: National Academy of Sciences publist_id: '3652' quality_controlled: 0 status: public title: Cytokinin regulates root meristem activity via modulation of the polar auxin transport type: journal_article volume: 106 year: '2009' ...