---
res:
  bibo_abstract:
  - 'Background: Whereas the majority of animals develop toward a predetermined body
    plan, plants show iterative growth and continually produce new organs and structures
    from actively dividing meristems. This raises an intriguing question: How are
    these newly developed organs patterned? In Arabidopsis embryos, radial symmetry
    is broken by the bisymmetric specification of the cotyledons in the apical domain.
    Subsequently, this bisymmetry is propagated to the root promeristem. Results:
    Here we present a mutually inhibitory feedback loop between auxin and cytokinin
    that sets distinct boundaries of hormonal output. Cytokinins promote the bisymmetric
    distribution of the PIN-FORMED (PIN) auxin efflux proteins, which channel auxin
    toward a central domain. High auxin promotes transcription of the cytokinin signaling
    inhibitor AHP6, which closes the interaction loop. This bisymmetric auxin response
    domain specifies the differentiation of protoxylem in a bisymmetric pattern. In
    embryonic roots, cytokinin is required to translate a bisymmetric auxin response
    in the cotyledons to a bisymmetric vascular pattern in the root promeristem. Conclusions:
    Our results present an interactive feedback loop between hormonal signaling and
    transport by which small biases in hormonal input are propagated into distinct
    signaling domains to specify the vascular pattern in the root meristem. It is
    an intriguing possibility that such a mechanism could transform radial patterns
    and allow continuous vascular connections between other newly emerging organs.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Anthony
      foaf_name: Bishopp, Anthony
      foaf_surname: Bishopp
  - foaf_Person:
      foaf_givenName: Hanna
      foaf_name: Help, Hanna
      foaf_surname: Help
  - foaf_Person:
      foaf_givenName: Sedeer
      foaf_name: El-Showk, Sedeer
      foaf_surname: El Showk
  - foaf_Person:
      foaf_givenName: Dolf
      foaf_name: Weijers, Dolf
      foaf_surname: Weijers
  - foaf_Person:
      foaf_givenName: Ben
      foaf_name: Scheres, Ben
      foaf_surname: Scheres
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Jirí Friml
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Eva
      foaf_name: Eva Benková
      foaf_surname: Benková
      foaf_workInfoHomepage: http://www.librecat.org/personId=38F4F166-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8510-9739
  - foaf_Person:
      foaf_givenName: Ari
      foaf_name: Mähönen, Ari Pekka
      foaf_surname: Mähönen
  - foaf_Person:
      foaf_givenName: Ykä
      foaf_name: Helariutta, Ykä
      foaf_surname: Helariutta
  bibo_doi: 10.1016/j.cub.2011.04.017
  bibo_issue: '11'
  bibo_volume: 21
  dct_date: 2011^xs_gYear
  dct_publisher: Cell Press@
  dct_title: A mutually inhibitory interaction between auxin and cytokinin specifies
    vascular pattern in roots@
...