---
_id: '3088'
abstract:
- lang: eng
  text: 'Background: Whereas the majority of animals develop toward a predetermined
    body plan, plants show iterative growth and continually produce new organs and
    structures from actively dividing meristems. This raises an intriguing question:
    How are these newly developed organs patterned? In Arabidopsis embryos, radial
    symmetry is broken by the bisymmetric specification of the cotyledons in the apical
    domain. Subsequently, this bisymmetry is propagated to the root promeristem. Results:
    Here we present a mutually inhibitory feedback loop between auxin and cytokinin
    that sets distinct boundaries of hormonal output. Cytokinins promote the bisymmetric
    distribution of the PIN-FORMED (PIN) auxin efflux proteins, which channel auxin
    toward a central domain. High auxin promotes transcription of the cytokinin signaling
    inhibitor AHP6, which closes the interaction loop. This bisymmetric auxin response
    domain specifies the differentiation of protoxylem in a bisymmetric pattern. In
    embryonic roots, cytokinin is required to translate a bisymmetric auxin response
    in the cotyledons to a bisymmetric vascular pattern in the root promeristem. Conclusions:
    Our results present an interactive feedback loop between hormonal signaling and
    transport by which small biases in hormonal input are propagated into distinct
    signaling domains to specify the vascular pattern in the root meristem. It is
    an intriguing possibility that such a mechanism could transform radial patterns
    and allow continuous vascular connections between other newly emerging organs.'
author:
- first_name: Anthony
  full_name: Bishopp, Anthony
  last_name: Bishopp
- first_name: Hanna
  full_name: Help, Hanna
  last_name: Help
- first_name: Sedeer
  full_name: El-Showk, Sedeer
  last_name: El Showk
- first_name: Dolf
  full_name: Weijers, Dolf
  last_name: Weijers
- first_name: Ben
  full_name: Scheres, Ben
  last_name: Scheres
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Eva
  full_name: Eva Benková
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Ari
  full_name: Mähönen, Ari Pekka
  last_name: Mähönen
- first_name: Ykä
  full_name: Helariutta, Ykä
  last_name: Helariutta
citation:
  ama: Bishopp A, Help H, El Showk S, et al. A mutually inhibitory interaction between
    auxin and cytokinin specifies vascular pattern in roots. <i>Current Biology</i>.
    2011;21(11):917-926. doi:<a href="https://doi.org/10.1016/j.cub.2011.04.017">10.1016/j.cub.2011.04.017</a>
  apa: Bishopp, A., Help, H., El Showk, S., Weijers, D., Scheres, B., Friml, J., …
    Helariutta, Y. (2011). A mutually inhibitory interaction between auxin and cytokinin
    specifies vascular pattern in roots. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2011.04.017">https://doi.org/10.1016/j.cub.2011.04.017</a>
  chicago: Bishopp, Anthony, Hanna Help, Sedeer El Showk, Dolf Weijers, Ben Scheres,
    Jiří Friml, Eva Benková, Ari Mähönen, and Ykä Helariutta. “A Mutually Inhibitory
    Interaction between Auxin and Cytokinin Specifies Vascular Pattern in Roots.”
    <i>Current Biology</i>. Cell Press, 2011. <a href="https://doi.org/10.1016/j.cub.2011.04.017">https://doi.org/10.1016/j.cub.2011.04.017</a>.
  ieee: A. Bishopp <i>et al.</i>, “A mutually inhibitory interaction between auxin
    and cytokinin specifies vascular pattern in roots,” <i>Current Biology</i>, vol.
    21, no. 11. Cell Press, pp. 917–926, 2011.
  ista: Bishopp A, Help H, El Showk S, Weijers D, Scheres B, Friml J, Benková E, Mähönen
    A, Helariutta Y. 2011. A mutually inhibitory interaction between auxin and cytokinin
    specifies vascular pattern in roots. Current Biology. 21(11), 917–926.
  mla: Bishopp, Anthony, et al. “A Mutually Inhibitory Interaction between Auxin and
    Cytokinin Specifies Vascular Pattern in Roots.” <i>Current Biology</i>, vol. 21,
    no. 11, Cell Press, 2011, pp. 917–26, doi:<a href="https://doi.org/10.1016/j.cub.2011.04.017">10.1016/j.cub.2011.04.017</a>.
  short: A. Bishopp, H. Help, S. El Showk, D. Weijers, B. Scheres, J. Friml, E. Benková,
    A. Mähönen, Y. Helariutta, Current Biology 21 (2011) 917–926.
date_created: 2018-12-11T12:01:18Z
date_published: 2011-06-07T00:00:00Z
date_updated: 2021-01-12T07:40:58Z
day: '07'
doi: 10.1016/j.cub.2011.04.017
extern: 1
intvolume: '        21'
issue: '11'
month: '06'
page: 917 - 926
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '3613'
quality_controlled: 0
status: public
title: A mutually inhibitory interaction between auxin and cytokinin specifies vascular
  pattern in roots
type: journal_article
volume: 21
year: '2011'
...