{"type":"journal_article","citation":{"mla":"Zhang, Jing, et al. “Inositol Trisphosphate-Induced Ca^2+ Signaling Modulates Auxin Transport and Pin Polarity.” <i>Developmental Cell</i>, vol. 20, no. 6, Cell Press, 2011, pp. 855–66, doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.05.013\">10.1016/j.devcel.2011.05.013</a>.","ieee":"J. Zhang <i>et al.</i>, “Inositol trisphosphate-induced ca^2+ signaling modulates auxin transport and pin polarity,” <i>Developmental Cell</i>, vol. 20, no. 6. Cell Press, pp. 855–866, 2011.","ama":"Zhang J, Vanneste S, Brewer P, et al. Inositol trisphosphate-induced ca^2+ signaling modulates auxin transport and pin polarity. <i>Developmental Cell</i>. 2011;20(6):855-866. doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.05.013\">10.1016/j.devcel.2011.05.013</a>","ista":"Zhang J, Vanneste S, Brewer P, Michniewicz M, Grones P, Kleine Vehn J, Löfke C, Teichmann T, Bielach A, Cannoot B, Hoyerová K, Chen X, Xue H, Benková E, Zažímalová E, Friml J. 2011. Inositol trisphosphate-induced ca^2+ signaling modulates auxin transport and pin polarity. Developmental Cell. 20(6), 855–866.","short":"J. Zhang, S. Vanneste, P. Brewer, M. Michniewicz, P. Grones, J. Kleine Vehn, C. Löfke, T. Teichmann, A. Bielach, B. Cannoot, K. Hoyerová, X. Chen, H. Xue, E. Benková, E. Zažímalová, J. Friml, Developmental Cell 20 (2011) 855–866.","apa":"Zhang, J., Vanneste, S., Brewer, P., Michniewicz, M., Grones, P., Kleine Vehn, J., … Friml, J. (2011). Inositol trisphosphate-induced ca^2+ signaling modulates auxin transport and pin polarity. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2011.05.013\">https://doi.org/10.1016/j.devcel.2011.05.013</a>","chicago":"Zhang, Jing, Steffen Vanneste, Philip Brewer, Marta Michniewicz, Peter Grones, Jürgen Kleine Vehn, Christian Löfke, et al. “Inositol Trisphosphate-Induced Ca^2+ Signaling Modulates Auxin Transport and Pin Polarity.” <i>Developmental Cell</i>. Cell Press, 2011. <a href=\"https://doi.org/10.1016/j.devcel.2011.05.013\">https://doi.org/10.1016/j.devcel.2011.05.013</a>."},"publication_status":"published","day":"14","date_created":"2018-12-11T12:01:18Z","publication":"Developmental Cell","date_published":"2011-06-14T00:00:00Z","_id":"3089","volume":20,"date_updated":"2021-01-12T07:40:58Z","author":[{"last_name":"Zhang","full_name":"Zhang, Jing","first_name":"Jing"},{"last_name":"Vanneste","full_name":"Vanneste, Steffen","first_name":"Steffen"},{"first_name":"Philip","full_name":"Brewer, Philip B","last_name":"Brewer"},{"last_name":"Michniewicz","full_name":"Michniewicz, Marta","first_name":"Marta"},{"last_name":"Grones","full_name":"Peter Grones","id":"399876EC-F248-11E8-B48F-1D18A9856A87","first_name":"Peter"},{"full_name":"Kleine-Vehn, Jürgen","last_name":"Kleine Vehn","first_name":"Jürgen"},{"last_name":"Löfke","full_name":"Löfke, Christian","first_name":"Christian"},{"first_name":"Thomas","full_name":"Teichmann, Thomas","last_name":"Teichmann"},{"first_name":"Agnieszka","full_name":"Bielach, Agnieszka","last_name":"Bielach"},{"first_name":"Bernard","full_name":"Cannoot, Bernard","last_name":"Cannoot"},{"first_name":"Klára","last_name":"Hoyerová","full_name":"Hoyerová, Klára"},{"last_name":"Chen","full_name":"Xu Chen","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","first_name":"Xu"},{"first_name":"Hong","full_name":"Xue, Hong-Wei","last_name":"Xue"},{"orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","full_name":"Eva Benková","first_name":"Eva"},{"first_name":"Eva","full_name":"Zažímalová, Eva","last_name":"Zažímalová"},{"first_name":"Jirí","last_name":"Friml","full_name":"Jirí Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"month":"06","doi":"10.1016/j.devcel.2011.05.013","title":"Inositol trisphosphate-induced ca^2+ signaling modulates auxin transport and pin polarity","abstract":[{"lang":"eng","text":"The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP 3) and cytosolic Ca 2+ levels. Pharmacological and genetic increases in InsP 3 or Ca 2+ levels also suppressed the PIN1 gain-of-function phenotypes and caused defects in basal PIN localization, auxin transport and auxin-mediated development. In contrast, the reductions in InsP 3 levels and Ca 2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP 3 and Ca 2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca 2+ signaling-related stimuli could influence auxin-mediated development."}],"year":"2011","issue":"6","publist_id":"3612","quality_controlled":0,"publisher":"Cell Press","intvolume":"        20","extern":1,"status":"public","page":"855 - 866"}