---
_id: '3097'
abstract:
- lang: eng
  text: Cytokinin is an important regulator of plant growth and development. In Arabidopsis
    thaliana, the two-component phosphorelay mediated through a family of histidine
    kinases and response regulators is recognized as the principal cytokinin signal
    transduction mechanism activating the complex transcriptional response to control
    various developmental processes. Here, we identified an alternative mode of cytokinin
    action that uses endocytic trafficking as a means to direct plant organogenesis.
    This activity occurs downstream of known cytokinin receptors but through a branch
    of the cytokinin signaling pathway that does not involve transcriptional regulation.
    We show that cytokinin regulates endocytic recycling of the auxin efflux carrier
    PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation
    of the lytic PIN1 degradation is not a default effect for general downregulation
    of proteins from plasma membranes, but a specific mechanism to rapidly modulate
    the auxin distribution in cytokinin-mediated developmental processes.
author:
- first_name: Peter
  full_name: Peter Marhavy
  id: 3F45B078-F248-11E8-B48F-1D18A9856A87
  last_name: Marhavy
  orcid: 0000-0001-5227-5741
- first_name: Agnieszka
  full_name: Bielach, Agnieszka
  last_name: Bielach
- first_name: Lindy
  full_name: Abas, Lindy
  last_name: Abas
- first_name: Anas
  full_name: Abuzeineh, Anas
  last_name: Abuzeineh
- first_name: Jérôme
  full_name: Duclercq, Jérôme
  last_name: Duclercq
- first_name: Hirokazu
  full_name: Tanaka, Hirokazu
  last_name: Tanaka
- first_name: Markéta
  full_name: Pařezová, Markéta
  last_name: Pařezová
- first_name: Jan
  full_name: Petrášek, Jan
  last_name: Petrášek
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Jürgen
  full_name: Kleine-Vehn, Jürgen
  last_name: Kleine Vehn
- first_name: Eva
  full_name: Eva Benková
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Marhavý P, Bielach A, Abas L, et al. Cytokinin modulates endocytic trafficking
    of PIN1 auxin efflux carrier to control plant organogenesis. <i>Developmental
    Cell</i>. 2011;21(4):796-804. doi:<a href="https://doi.org/10.1016/j.devcel.2011.08.014">10.1016/j.devcel.2011.08.014</a>
  apa: Marhavý, P., Bielach, A., Abas, L., Abuzeineh, A., Duclercq, J., Tanaka, H.,
    … Benková, E. (2011). Cytokinin modulates endocytic trafficking of PIN1 auxin
    efflux carrier to control plant organogenesis. <i>Developmental Cell</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.devcel.2011.08.014">https://doi.org/10.1016/j.devcel.2011.08.014</a>
  chicago: Marhavý, Peter, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jérôme Duclercq,
    Hirokazu Tanaka, Markéta Pařezová, et al. “Cytokinin Modulates Endocytic Trafficking
    of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” <i>Developmental
    Cell</i>. Cell Press, 2011. <a href="https://doi.org/10.1016/j.devcel.2011.08.014">https://doi.org/10.1016/j.devcel.2011.08.014</a>.
  ieee: P. Marhavý <i>et al.</i>, “Cytokinin modulates endocytic trafficking of PIN1
    auxin efflux carrier to control plant organogenesis,” <i>Developmental Cell</i>,
    vol. 21, no. 4. Cell Press, pp. 796–804, 2011.
  ista: Marhavý P, Bielach A, Abas L, Abuzeineh A, Duclercq J, Tanaka H, Pařezová
    M, Petrášek J, Friml J, Kleine Vehn J, Benková E. 2011. Cytokinin modulates endocytic
    trafficking of PIN1 auxin efflux carrier to control plant organogenesis. Developmental
    Cell. 21(4), 796–804.
  mla: Marhavý, Peter, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin
    Efflux Carrier to Control Plant Organogenesis.” <i>Developmental Cell</i>, vol.
    21, no. 4, Cell Press, 2011, pp. 796–804, doi:<a href="https://doi.org/10.1016/j.devcel.2011.08.014">10.1016/j.devcel.2011.08.014</a>.
  short: P. Marhavý, A. Bielach, L. Abas, A. Abuzeineh, J. Duclercq, H. Tanaka, M.
    Pařezová, J. Petrášek, J. Friml, J. Kleine Vehn, E. Benková, Developmental Cell
    21 (2011) 796–804.
date_created: 2018-12-11T12:01:22Z
date_published: 2011-10-18T00:00:00Z
date_updated: 2021-01-12T07:41:02Z
day: '18'
doi: 10.1016/j.devcel.2011.08.014
extern: 1
intvolume: '        21'
issue: '4'
month: '10'
page: 796 - 804
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3603'
quality_controlled: 0
status: public
title: Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control
  plant organogenesis
type: journal_article
volume: 21
year: '2011'
...