---
_id: '3112'
abstract:
- lang: eng
text: The dynamic spatial and temporal distribution of the crucial plant signaling
molecule auxin is achieved by feedback coordination of auxin signaling and intercellular
auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed
predominantly to its effect on transcription; however, an alternative pathway
involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated
endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation
in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector
RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated
endocytosis, as well as for its feedback regulation by auxin. Genetic analysis
revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This
signaling circuit is also involved in the feedback regulation of PIN-FORMED 1
(PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis)
and corresponding auxin transport-mediated processes, including root gravitropism
and leave vascular tissue patterning. Our findings suggest that the signaling
module auxin-ABP1-ROP6/RIC1-clathrin-PIN1/PIN2 is a shared component of the feedback
regulation of auxin transport during both root and aerial development.
author:
- first_name: Xu
full_name: Xu Chen
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Satoshi
full_name: Naramoto, Satoshi
last_name: Naramoto
- first_name: Stéphanie
full_name: Robert, Stéphanie
last_name: Robert
- first_name: Ricardo
full_name: Tejos, Ricardo
last_name: Tejos
- first_name: Christian
full_name: Löfke, Christian
last_name: Löfke
- first_name: Deshu
full_name: Lin, Deshu
last_name: Lin
- first_name: Zhenbiao
full_name: Yang, Zhenbiao
last_name: Yang
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Chen X, Naramoto S, Robert S, et al. ABP1 and ROP6 GTPase signaling regulate
clathrin mediated endocytosis in Arabidopsis roots. Current Biology. 2012;22(14):1326-1332.
doi:10.1016/j.cub.2012.05.020
apa: Chen, X., Naramoto, S., Robert, S., Tejos, R., Löfke, C., Lin, D., … Friml,
J. (2012). ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis
in Arabidopsis roots. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2012.05.020
chicago: Chen, Xu, Satoshi Naramoto, Stéphanie Robert, Ricardo Tejos, Christian
Löfke, Deshu Lin, Zhenbiao Yang, and Jiří Friml. “ABP1 and ROP6 GTPase Signaling
Regulate Clathrin Mediated Endocytosis in Arabidopsis Roots.” Current Biology.
Cell Press, 2012. https://doi.org/10.1016/j.cub.2012.05.020.
ieee: X. Chen et al., “ABP1 and ROP6 GTPase signaling regulate clathrin mediated
endocytosis in Arabidopsis roots,” Current Biology, vol. 22, no. 14. Cell
Press, pp. 1326–1332, 2012.
ista: Chen X, Naramoto S, Robert S, Tejos R, Löfke C, Lin D, Yang Z, Friml J. 2012.
ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis
roots. Current Biology. 22(14), 1326–1332.
mla: Chen, Xu, et al. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin Mediated
Endocytosis in Arabidopsis Roots.” Current Biology, vol. 22, no. 14, Cell
Press, 2012, pp. 1326–32, doi:10.1016/j.cub.2012.05.020.
short: X. Chen, S. Naramoto, S. Robert, R. Tejos, C. Löfke, D. Lin, Z. Yang, J.
Friml, Current Biology 22 (2012) 1326–1332.
date_created: 2018-12-11T12:01:27Z
date_published: 2012-07-24T00:00:00Z
date_updated: 2021-01-12T07:41:08Z
day: '24'
doi: 10.1016/j.cub.2012.05.020
extern: 1
intvolume: ' 22'
issue: '14'
month: '07'
page: 1326 - 1332
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '3587'
quality_controlled: 0
status: public
title: ABP1 and ROP6 GTPase signaling regulate clathrin mediated endocytosis in Arabidopsis
roots
type: journal_article
volume: 22
year: '2012'
...