[{"type":"journal_article","extern":1,"abstract":[{"text":"Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H2O2)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly with the invaginating midgut primordium as it enters the embryo; however, in embryos from jafrac1 mutant mothers this association is disrupted, leaving some PGCs trailing on the outside of the embryo. We observed similar phenotypes in embryos from DE-cadherin/shotgun (shg) mutant mothers and were able to rescue the jafrac1 phenotype by increasing DE-cadherin levels. This and our biochemical evidence strongly suggest that Jafrac1-mediated reduction of H2O2 is required to maintain DE-cadherin protein levels in the early embryo. Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion.","lang":"eng"}],"issue":"2","publist_id":"3541","status":"public","title":"Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion","publication_status":"published","publisher":"Cell Press","intvolume":" 20","year":"2011","_id":"3154","date_updated":"2021-01-12T07:41:26Z","date_created":"2018-12-11T12:01:42Z","volume":20,"author":[{"full_name":"DeGennaro, Matthew","last_name":"Degennaro","first_name":"Matthew"},{"last_name":"Hurd","first_name":"Thomas","full_name":"Hurd, Thomas R"},{"id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8323-8353","first_name":"Daria E","last_name":"Siekhaus","full_name":"Daria Siekhaus"},{"last_name":"Biteau","first_name":"Benoit","full_name":"Biteau, Benoit"},{"last_name":"Jasper","first_name":"Heinrich","full_name":"Jasper, Heinrich"},{"last_name":"Lehmann","first_name":"Ruth","full_name":"Lehmann, Ruth"}],"month":"02","day":"15","quality_controlled":0,"page":"233 - 243","publication":"Developmental Cell","citation":{"ista":"Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. 2011. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. 20(2), 233–243.","ieee":"M. Degennaro, T. Hurd, D. E. Siekhaus, B. Biteau, H. Jasper, and R. Lehmann, “Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion,” Developmental Cell, vol. 20, no. 2. Cell Press, pp. 233–243, 2011.","apa":"Degennaro, M., Hurd, T., Siekhaus, D. E., Biteau, B., Jasper, H., & Lehmann, R. (2011). Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2010.12.007","ama":"Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. 2011;20(2):233-243. doi:10.1016/j.devcel.2010.12.007","chicago":"Degennaro, Matthew, Thomas Hurd, Daria E Siekhaus, Benoit Biteau, Heinrich Jasper, and Ruth Lehmann. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” Developmental Cell. Cell Press, 2011. https://doi.org/10.1016/j.devcel.2010.12.007.","mla":"Degennaro, Matthew, et al. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” Developmental Cell, vol. 20, no. 2, Cell Press, 2011, pp. 233–43, doi:10.1016/j.devcel.2010.12.007.","short":"M. Degennaro, T. Hurd, D.E. Siekhaus, B. Biteau, H. Jasper, R. Lehmann, Developmental Cell 20 (2011) 233–243."},"doi":"10.1016/j.devcel.2010.12.007","date_published":"2011-02-15T00:00:00Z"}]