--- _id: '3154' abstract: - lang: eng text: Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H2O2)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly with the invaginating midgut primordium as it enters the embryo; however, in embryos from jafrac1 mutant mothers this association is disrupted, leaving some PGCs trailing on the outside of the embryo. We observed similar phenotypes in embryos from DE-cadherin/shotgun (shg) mutant mothers and were able to rescue the jafrac1 phenotype by increasing DE-cadherin levels. This and our biochemical evidence strongly suggest that Jafrac1-mediated reduction of H2O2 is required to maintain DE-cadherin protein levels in the early embryo. Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion. author: - first_name: Matthew full_name: DeGennaro, Matthew last_name: Degennaro - first_name: Thomas full_name: Hurd, Thomas R last_name: Hurd - first_name: Daria E full_name: Daria Siekhaus id: 3D224B9E-F248-11E8-B48F-1D18A9856A87 last_name: Siekhaus orcid: 0000-0001-8323-8353 - first_name: Benoit full_name: Biteau, Benoit last_name: Biteau - first_name: Heinrich full_name: Jasper, Heinrich last_name: Jasper - first_name: Ruth full_name: Lehmann, Ruth last_name: Lehmann citation: ama: Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. 2011;20(2):233-243. doi:10.1016/j.devcel.2010.12.007 apa: Degennaro, M., Hurd, T., Siekhaus, D. E., Biteau, B., Jasper, H., & Lehmann, R. (2011). Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2010.12.007 chicago: Degennaro, Matthew, Thomas Hurd, Daria E Siekhaus, Benoit Biteau, Heinrich Jasper, and Ruth Lehmann. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” Developmental Cell. Cell Press, 2011. https://doi.org/10.1016/j.devcel.2010.12.007. ieee: M. Degennaro, T. Hurd, D. E. Siekhaus, B. Biteau, H. Jasper, and R. Lehmann, “Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion,” Developmental Cell, vol. 20, no. 2. Cell Press, pp. 233–243, 2011. ista: Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. 2011. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. 20(2), 233–243. mla: Degennaro, Matthew, et al. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” Developmental Cell, vol. 20, no. 2, Cell Press, 2011, pp. 233–43, doi:10.1016/j.devcel.2010.12.007. short: M. Degennaro, T. Hurd, D.E. Siekhaus, B. Biteau, H. Jasper, R. Lehmann, Developmental Cell 20 (2011) 233–243. date_created: 2018-12-11T12:01:42Z date_published: 2011-02-15T00:00:00Z date_updated: 2021-01-12T07:41:26Z day: '15' doi: 10.1016/j.devcel.2010.12.007 extern: 1 intvolume: ' 20' issue: '2' month: '02' page: 233 - 243 publication: Developmental Cell publication_status: published publisher: Cell Press publist_id: '3541' quality_controlled: 0 status: public title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion type: journal_article volume: 20 year: '2011' ...