---
_id: '3154'
abstract:
- lang: eng
text: Regulated adhesion between cells and their environment is critical for normal
cell migration. We have identified mutations in a gene encoding the Drosophila
hydrogen peroxide (H2O2)-degrading enzyme Jafrac1, which lead to germ cell adhesion
defects. During gastrulation, primordial germ cells (PGCs) associate tightly with
the invaginating midgut primordium as it enters the embryo; however, in embryos
from jafrac1 mutant mothers this association is disrupted, leaving some PGCs trailing
on the outside of the embryo. We observed similar phenotypes in embryos from DE-cadherin/shotgun
(shg) mutant mothers and were able to rescue the jafrac1 phenotype by increasing
DE-cadherin levels. This and our biochemical evidence strongly suggest that Jafrac1-mediated
reduction of H2O2 is required to maintain DE-cadherin protein levels in the early
embryo. Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated
adhesion.
author:
- first_name: Matthew
full_name: DeGennaro, Matthew
last_name: Degennaro
- first_name: Thomas
full_name: Hurd, Thomas R
last_name: Hurd
- first_name: Daria E
full_name: Daria Siekhaus
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Benoit
full_name: Biteau, Benoit
last_name: Biteau
- first_name: Heinrich
full_name: Jasper, Heinrich
last_name: Jasper
- first_name: Ruth
full_name: Lehmann, Ruth
last_name: Lehmann
citation:
ama: Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin
stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental
Cell. 2011;20(2):233-243. doi:10.1016/j.devcel.2010.12.007
apa: Degennaro, M., Hurd, T., Siekhaus, D. E., Biteau, B., Jasper, H., & Lehmann,
R. (2011). Peroxiredoxin stabilization of DE-cadherin promotes primordial germ
cell adhesion. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2010.12.007
chicago: Degennaro, Matthew, Thomas Hurd, Daria E Siekhaus, Benoit Biteau, Heinrich
Jasper, and Ruth Lehmann. “Peroxiredoxin Stabilization of DE-Cadherin Promotes
Primordial Germ Cell Adhesion.” Developmental Cell. Cell Press, 2011. https://doi.org/10.1016/j.devcel.2010.12.007.
ieee: M. Degennaro, T. Hurd, D. E. Siekhaus, B. Biteau, H. Jasper, and R. Lehmann,
“Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion,”
Developmental Cell, vol. 20, no. 2. Cell Press, pp. 233–243, 2011.
ista: Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. 2011. Peroxiredoxin
stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental
Cell. 20(2), 233–243.
mla: Degennaro, Matthew, et al. “Peroxiredoxin Stabilization of DE-Cadherin Promotes
Primordial Germ Cell Adhesion.” Developmental Cell, vol. 20, no. 2, Cell
Press, 2011, pp. 233–43, doi:10.1016/j.devcel.2010.12.007.
short: M. Degennaro, T. Hurd, D.E. Siekhaus, B. Biteau, H. Jasper, R. Lehmann, Developmental
Cell 20 (2011) 233–243.
date_created: 2018-12-11T12:01:42Z
date_published: 2011-02-15T00:00:00Z
date_updated: 2021-01-12T07:41:26Z
day: '15'
doi: 10.1016/j.devcel.2010.12.007
extern: 1
intvolume: ' 20'
issue: '2'
month: '02'
page: 233 - 243
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3541'
quality_controlled: 0
status: public
title: Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion
type: journal_article
volume: 20
year: '2011'
...