---
res:
  bibo_abstract:
  - The functional role of AMPA receptor (AMPAR)-mediated synaptic signaling between
    neurons and oligodendrocyte precursor cells (OPCs) remains enigmatic. We modified
    the properties of AMPARs at axon-OPC synapses in the mouse corpus callosum in
    vivo during the peak of myelination by targeting the GluA2 subunit. Expression
    of the unedited (Ca2+ permeable) or the pore-dead GluA2 subunit of AMPARs triggered
    proliferation of OPCs and reduced their differentiation into oligodendrocytes.
    Expression of the cytoplasmic C-terminal (GluA2(813-862)) of the GluA2 subunit
    (C-tail), a modification designed to affect the interaction between GluA2 and
    AMPAR-binding proteins and to perturb trafficking of GluA2-containing AMPARs,
    decreased the differentiation of OPCs without affecting their proliferation. These
    findings suggest that ionotropic and non-ionotropic properties of AMPARs in OPCs,
    as well as specific aspects of AMPAR-mediated signaling at axon-OPC synapses in
    the mouse corpus callosum, are important for balancing the response of OPCs to
    proliferation and differentiation cues. In the brain, oligodendrocyte precursor
    cells (OPCs) receive glutamatergic AMPA-receptor-mediated synaptic input from
    neurons. Chen et al. show that modifying AMPA-receptor properties at axon-OPC
    synapses alters proliferation and differentiation of OPCs. This expands the traditional
    view of synaptic transmission by suggesting neurons also use synapses to modulate
    behavior of glia.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Ting
      foaf_name: Chen, Ting
      foaf_surname: Chen
  - foaf_Person:
      foaf_givenName: Bartosz
      foaf_name: Kula, Bartosz
      foaf_surname: Kula
  - foaf_Person:
      foaf_givenName: Balint
      foaf_name: Nagy, Balint
      foaf_surname: Nagy
      foaf_workInfoHomepage: http://www.librecat.org/personId=30F830CE-02D1-11E9-9BAA-DAF4881429F2
    orcid: 0000-0002-4002-4686
  - foaf_Person:
      foaf_givenName: Ruxandra
      foaf_name: Barzan, Ruxandra
      foaf_surname: Barzan
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Gall, Andrea
      foaf_surname: Gall
  - foaf_Person:
      foaf_givenName: Ingrid
      foaf_name: Ehrlich, Ingrid
      foaf_surname: Ehrlich
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Kukley, Maria
      foaf_surname: Kukley
  bibo_doi: 10.1016/j.celrep.2018.09.066
  bibo_issue: '4'
  bibo_volume: 25
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000448219500005
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: In Vivo regulation of Oligodendrocyte processor cell proliferation and
    differentiation by the AMPA-receptor Subunit GluA2@
...