---
_id: '32'
abstract:
- lang: eng
  text: The functional role of AMPA receptor (AMPAR)-mediated synaptic signaling between
    neurons and oligodendrocyte precursor cells (OPCs) remains enigmatic. We modified
    the properties of AMPARs at axon-OPC synapses in the mouse corpus callosum in
    vivo during the peak of myelination by targeting the GluA2 subunit. Expression
    of the unedited (Ca2+ permeable) or the pore-dead GluA2 subunit of AMPARs triggered
    proliferation of OPCs and reduced their differentiation into oligodendrocytes.
    Expression of the cytoplasmic C-terminal (GluA2(813-862)) of the GluA2 subunit
    (C-tail), a modification designed to affect the interaction between GluA2 and
    AMPAR-binding proteins and to perturb trafficking of GluA2-containing AMPARs,
    decreased the differentiation of OPCs without affecting their proliferation. These
    findings suggest that ionotropic and non-ionotropic properties of AMPARs in OPCs,
    as well as specific aspects of AMPAR-mediated signaling at axon-OPC synapses in
    the mouse corpus callosum, are important for balancing the response of OPCs to
    proliferation and differentiation cues. In the brain, oligodendrocyte precursor
    cells (OPCs) receive glutamatergic AMPA-receptor-mediated synaptic input from
    neurons. Chen et al. show that modifying AMPA-receptor properties at axon-OPC
    synapses alters proliferation and differentiation of OPCs. This expands the traditional
    view of synaptic transmission by suggesting neurons also use synapses to modulate
    behavior of glia.
acknowledgement: This work was supported by Deutsche Forschungsgemeinschaft (DFG)
  grant KU2569/1-1 (to M.K.); DFG project EXC307Centre for Integrative Neuroscience
  (CIN), including grant Pool Project 2011-12 (jointly to M.K. and I.E.); and the
  Charitable Hertie Foundation (to I.E.). CIN is an Excellence Cluster funded by the
  DFG within the framework of the Excellence Initiative for 2008–2018. M.K. is supported
  by the Tistou & Charlotte Kerstan Foundation.
article_processing_charge: No
author:
- first_name: Ting
  full_name: Chen, Ting
  last_name: Chen
- first_name: Bartosz
  full_name: Kula, Bartosz
  last_name: Kula
- first_name: Balint
  full_name: Nagy, Balint
  id: 30F830CE-02D1-11E9-9BAA-DAF4881429F2
  last_name: Nagy
  orcid: 0000-0002-4002-4686
- first_name: Ruxandra
  full_name: Barzan, Ruxandra
  last_name: Barzan
- first_name: Andrea
  full_name: Gall, Andrea
  last_name: Gall
- first_name: Ingrid
  full_name: Ehrlich, Ingrid
  last_name: Ehrlich
- first_name: Maria
  full_name: Kukley, Maria
  last_name: Kukley
citation:
  ama: Chen T, Kula B, Nagy B, et al. In Vivo regulation of Oligodendrocyte processor
    cell proliferation and differentiation by the AMPA-receptor Subunit GluA2. <i>Cell
    Reports</i>. 2018;25(4):852-861.e7. doi:<a href="https://doi.org/10.1016/j.celrep.2018.09.066">10.1016/j.celrep.2018.09.066</a>
  apa: Chen, T., Kula, B., Nagy, B., Barzan, R., Gall, A., Ehrlich, I., &#38; Kukley,
    M. (2018). In Vivo regulation of Oligodendrocyte processor cell proliferation
    and differentiation by the AMPA-receptor Subunit GluA2. <i>Cell Reports</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.celrep.2018.09.066">https://doi.org/10.1016/j.celrep.2018.09.066</a>
  chicago: Chen, Ting, Bartosz Kula, Balint Nagy, Ruxandra Barzan, Andrea Gall, Ingrid
    Ehrlich, and Maria Kukley. “In Vivo Regulation of Oligodendrocyte Processor Cell
    Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2.” <i>Cell
    Reports</i>. Elsevier, 2018. <a href="https://doi.org/10.1016/j.celrep.2018.09.066">https://doi.org/10.1016/j.celrep.2018.09.066</a>.
  ieee: T. Chen <i>et al.</i>, “In Vivo regulation of Oligodendrocyte processor cell
    proliferation and differentiation by the AMPA-receptor Subunit GluA2,” <i>Cell
    Reports</i>, vol. 25, no. 4. Elsevier, p. 852–861.e7, 2018.
  ista: Chen T, Kula B, Nagy B, Barzan R, Gall A, Ehrlich I, Kukley M. 2018. In Vivo
    regulation of Oligodendrocyte processor cell proliferation and differentiation
    by the AMPA-receptor Subunit GluA2. Cell Reports. 25(4), 852–861.e7.
  mla: Chen, Ting, et al. “In Vivo Regulation of Oligodendrocyte Processor Cell Proliferation
    and Differentiation by the AMPA-Receptor Subunit GluA2.” <i>Cell Reports</i>,
    vol. 25, no. 4, Elsevier, 2018, p. 852–861.e7, doi:<a href="https://doi.org/10.1016/j.celrep.2018.09.066">10.1016/j.celrep.2018.09.066</a>.
  short: T. Chen, B. Kula, B. Nagy, R. Barzan, A. Gall, I. Ehrlich, M. Kukley, Cell
    Reports 25 (2018) 852–861.e7.
date_created: 2018-12-11T11:44:16Z
date_published: 2018-10-23T00:00:00Z
date_updated: 2023-09-11T14:13:32Z
day: '23'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.1016/j.celrep.2018.09.066
external_id:
  isi:
  - '000448219500005'
file:
- access_level: open_access
  checksum: d9f74277fd57176e04732707d575cf08
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T12:42:57Z
  date_updated: 2020-07-14T12:46:03Z
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  file_name: 2018_CellReports_Chen.pdf
  file_size: 4461997
  relation: main_file
file_date_updated: 2020-07-14T12:46:03Z
fulldoi: https://doi.org/10.1016/j.celrep.2018.09.066
has_accepted_license: '1'
intvolume: '        25'
isi: 1
issue: '4'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 852 - 861.e7
publication: Cell Reports
publication_status: published
publisher: Elsevier
publist_id: '8023'
quality_controlled: '1'
scopus_import: '1'
status: public
title: In Vivo regulation of Oligodendrocyte processor cell proliferation and differentiation
  by the AMPA-receptor Subunit GluA2
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 25
year: '2018'
...