---
res:
  bibo_abstract:
  - Fast-spiking, parvalbumin-expressing GABAergic interneurons (PV+-BCs) express
    a complex machinery of rapid signaling mechanisms, including specialized voltage-gated
    ion channels to generate brief action potentials (APs). However, short APs are
    associated with overlapping Na+ and K+ fluxes and are therefore energetically
    expensive. How the potentially vicious combination of high AP frequency and inefficient
    spike generation can be reconciled with limited energy supply is presently unclear.
    To address this question, we performed direct recordings from the PV+-BC axon,
    the subcellular structure where active conductances for AP initiation and propagation
    are located. Surprisingly, the energy required for the AP was, on average, only
    ∼1.6 times the theoretical minimum. High energy efficiency emerged from the combination
    of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels,
    which minimized ion flux overlap during APs. Thus, the complementary tuning of
    axonal Na+ and K+ channel gating optimizes both fast signaling properties and
    metabolic efficiency. Hu et al. demonstrate that action potentials in parvalbumin-expressing
    GABAergic interneuron axons are energetically efficient, which is highly unexpected
    given their brief duration. High energy efficiency emerges from the combination
    of fast inactivation of voltage-gated Na+ channels and delayed activation of Kv3
    channels in the axon. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Hua
      foaf_name: Hu, Hua
      foaf_surname: Hu
      foaf_workInfoHomepage: http://www.librecat.org/personId=4AC0145C-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Fabian
      foaf_name: Roth, Fabian
      foaf_surname: Roth
  - foaf_Person:
      foaf_givenName: David H
      foaf_name: Vandael, David H
      foaf_surname: Vandael
      foaf_workInfoHomepage: http://www.librecat.org/personId=3AE48E0A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7577-1676
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1016/j.neuron.2018.02.024
  bibo_issue: '1'
  bibo_volume: 98
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000429192100016
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Complementary tuning of Na+ and K+ channel gating underlies fast and
    energy-efficient action potentials in GABAergic interneuron axons@
...