---
res:
  bibo_abstract:
  - Living cells must control the reading out or "expression" of information
    encoded in their genomes, and this regulation often is mediated by transcription
    factors--proteins that bind to DNA and either enhance or repress the expression
    of nearby genes. But the expression of transcription factor proteins is itself
    regulated, and many transcription factors regulate their own expression in addition
    to responding to other input signals. Here we analyze the simplest of such self-regulatory
    circuits, asking how parameters can be chosen to optimize information transmission
    from inputs to outputs in the steady state. Some nonzero level of self-regulation
    is almost always optimal, with self-activation dominant when transcription factor
    concentrations are low and self-repression dominant when concentrations are high.
    In steady state the optimal self-activation is never strong enough to induce bistability,
    although there is a limit in which the optimal parameters are very close to the
    critical point.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Aleksandra
      foaf_name: Walczak, Aleksandra
      foaf_surname: Walczak
  - foaf_Person:
      foaf_givenName: William
      foaf_name: Bialek, William
      foaf_surname: Bialek
  bibo_doi: 10.1103/PhysRevE.85.041903
  bibo_issue: '4'
  bibo_volume: 85
  dct_date: 2012^xs_gYear
  dct_identifier:
  - UT:000302410200006
  dct_language: eng
  dct_publisher: American Institute of Physics@
  dct_title: Optimizing information flow in small genetic networks. III. A self-interacting
    gene@
...