Optimizing information flow in small genetic networks. III. A self-interacting gene

article Optimizing information flow in small genetic networks. III. A self-interacting gene published yes Gasper Tkacik author 3D494DCA-F248-11E8-B48F-1D18A9856A870000-0002-6699-1455 Aleksandra Walczak author William Bialek author GaTk department Living cells must control the reading out or "expression" of information encoded in their genomes, and this regulation often is mediated by transcription factors--proteins that bind to DNA and either enhance or repress the expression of nearby genes. But the expression of transcription factor proteins is itself regulated, and many transcription factors regulate their own expression in addition to responding to other input signals. Here we analyze the simplest of such self-regulatory circuits, asking how parameters can be chosen to optimize information transmission from inputs to outputs in the steady state. Some nonzero level of self-regulation is almost always optimal, with self-activation dominant when transcription factor concentrations are low and self-repression dominant when concentrations are high. In steady state the optimal self-activation is never strong enough to induce bistability, although there is a limit in which the optimal parameters are very close to the critical point. American Physical Society2012 eng Physical Review E 1112.5026 00030241020000610.1103/PhysRevE.85.041903 854 Tkačik G, Walczak A, Bialek W. 2012. Optimizing information flow in small genetic networks. III. A self-interacting gene. Physical Review E. 85(4), 041903. Tkačik, Gašper, Aleksandra Walczak, and William Bialek. “Optimizing Information Flow in Small Genetic Networks. III. A Self-Interacting Gene.” Physical Review E. American Physical Society, 2012. <a href="https://doi.org/10.1103/PhysRevE.85.041903">https://doi.org/10.1103/PhysRevE.85.041903</a>. G. Tkačik, A. Walczak, and W. Bialek, “Optimizing information flow in small genetic networks. III. A self-interacting gene,” Physical Review E, vol. 85, no. 4. American Physical Society, 2012. Tkačik G, Walczak A, Bialek W. Optimizing information flow in small genetic networks. III. A self-interacting gene. Physical Review E. 2012;85(4). doi:<a href="https://doi.org/10.1103/PhysRevE.85.041903">10.1103/PhysRevE.85.041903</a> Tkačik, G., Walczak, A., & Bialek, W. (2012). Optimizing information flow in small genetic networks. III. A self-interacting gene. Physical Review E. American Physical Society. <a href="https://doi.org/10.1103/PhysRevE.85.041903">https://doi.org/10.1103/PhysRevE.85.041903</a> G. Tkačik, A. Walczak, W. Bialek, Physical Review E 85 (2012). Tkačik, Gašper, et al. “Optimizing Information Flow in Small Genetic Networks. III. A Self-Interacting Gene.” Physical Review E, vol. 85, no. 4, 041903, American Physical Society, 2012, doi:<a href="https://doi.org/10.1103/PhysRevE.85.041903">10.1103/PhysRevE.85.041903</a>. 32622018-12-11T12:02:20Z2026-08-12T14:29:02Z