---
res:
  bibo_abstract:
  - "Viral manipulation of transduction pathways associated with key cellular functions
    such as survival, response to microbial infection, and cytoskeleton reorganization
    can provide the supportive milieu for a productive infection. Here, we demonstrate
    that vaccinia virus (VACV) infection leads to activation of the stress-activated
    protein kinase (SAPK)/extracellular signal-regulated kinase (ERK) 4/7 (MKK4/7)-c-Jun
    N-terminal protein kinase 1/2 (JNK1/2) pathway; further, the stimulation of this
    pathway requires postpenetration, prereplicative events in the viral replication
    cycle. Although the formation of intracellular mature virus (IMV) was not affected
    in MKK4/7- or JNK1/2-knockout (KO) cells, we did note an accentuated deregulation
    of microtubule and actin network organization in infected JNK1/2-KO cells. This
    was followed by deregulated viral trafficking to the periphery and enhanced enveloped
    particle release. Furthermore, VACV infection induced alterations in the cell
    contractility and morphology, and cell migration was reduced in the JNK-KO cells.
    In addition, phosphorylation of proteins implicated with early cell contractility
    and cell migration, such as microtubule-associated protein 1B and paxillin, respectively,
    was not detected in the VACV-infected KO cells. In sum, our findings uncover a
    regulatory role played by the MKK4/7-JNK1/2 pathway in cytoskeleton reorganization
    during VACV infection.\r\n@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Pereira, Anna
      foaf_surname: Pereira
  - foaf_Person:
      foaf_givenName: Flávia
      foaf_name: Leite, Flávia
      foaf_surname: Leite
      foaf_workInfoHomepage: http://www.librecat.org/personId=36705F98-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Bruno
      foaf_name: Brasil, Bruno
      foaf_surname: Brasil
  - foaf_Person:
      foaf_givenName: Jamaria
      foaf_name: Soares Martins, Jamaria
      foaf_surname: Soares Martins
  - foaf_Person:
      foaf_givenName: Alice
      foaf_name: Torres, Alice
      foaf_surname: Torres
  - foaf_Person:
      foaf_givenName: Paulo
      foaf_name: Pimenta, Paulo
      foaf_surname: Pimenta
  - foaf_Person:
      foaf_givenName: Thais
      foaf_name: Souto Padrón, Thais
      foaf_surname: Souto Padrón
  - foaf_Person:
      foaf_givenName: Paula
      foaf_name: Tranktman, Paula
      foaf_surname: Tranktman
  - foaf_Person:
      foaf_givenName: Paulo
      foaf_name: Ferreira, Paulo
      foaf_surname: Ferreira
  - foaf_Person:
      foaf_givenName: Erna
      foaf_name: Kroon, Erna
      foaf_surname: Kroon
  - foaf_Person:
      foaf_givenName: Cláudio
      foaf_name: Bonjardim, Cláudio
      foaf_surname: Bonjardim
  bibo_doi: 10.1128/JVI.05638-11
  bibo_issue: '1'
  bibo_volume: 86
  dct_date: 2012^xs_gYear
  dct_identifier:
  - UT:000298347700017
  dct_language: eng
  dct_publisher: ASM@
  dct_title: A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and
    cytoskeleton reorganization@
  fabio_hasPubmedId: '22031940'
...