---
res:
  bibo_abstract:
  - Biological traits result in part from interactions between different genetic loci.
    This can lead to sign epistasis, in which a beneficial adaptation involves a combination
    of individually deleterious or neutral mutations; in this case, a population must
    cross a “fitness valley” to adapt. Recombination can assist this process by combining
    mutations from different individuals or retard it by breaking up the adaptive
    combination. Here, we analyze the simplest fitness valley, in which an adaptation
    requires one mutation at each of two loci to provide a fitness benefit. We present
    a theoretical analysis of the effect of recombination on the valley-crossing process
    across the full spectrum of possible parameter regimes. We find that low recombination
    rates can speed up valley crossing relative to the asexual case, while higher
    recombination rates slow down valley crossing, with the transition between the
    two regimes occurring when the recombination rate between the loci is approximately
    equal to the selective advantage provided by the adaptation. In large populations,
    if the recombination rate is high and selection against single mutants is substantial,
    the time to cross the valley grows exponentially with population size, effectively
    meaning that the population cannot acquire the adaptation. Recombination at the
    optimal (low) rate can reduce the valley-crossing time by up to several orders
    of magnitude relative to that in an asexual population. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Weissman, Daniel
      foaf_surname: Weissman
      foaf_workInfoHomepage: http://www.librecat.org/personId=2D0CE020-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Marcus
      foaf_name: Feldman, Marcus
      foaf_surname: Feldman
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Fisher, Daniel
      foaf_surname: Fisher
  bibo_doi: 10.1534/genetics.110.123240
  bibo_issue: '4'
  bibo_volume: 186
  dct_date: 2010^xs_gYear
  dct_identifier:
  - UT:000285297000025
  dct_language: eng
  dct_publisher: Genetics Society of America@
  dct_title: The rate of fitness-valley crossing in sexual populations@
...