---
_id: '3374'
abstract:
- lang: eng
text: Genetic regulatory networks enable cells to respond to changes in internal
and external conditions by dynamically coordinating their gene expression profiles.
Our ability to make quantitative measurements in these biochemical circuits has
deepened our understanding of what kinds of computations genetic regulatory networks
can perform, and with what reliability. These advances have motivated researchers
to look for connections between the architecture and function of genetic regulatory
networks. Transmitting information between a network's inputs and outputs has
been proposed as one such possible measure of function, relevant in certain biological
contexts. Here we summarize recent developments in the application of information
theory to gene regulatory networks. We first review basic concepts in information
theory necessary for understanding recent work. We then discuss the functional
complexity of gene regulation, which arises from the molecular nature of the regulatory
interactions. We end by reviewing some experiments that support the view that
genetic networks responsible for early development of multicellular organisms
might be maximizing transmitted 'positional information'.
article_number: '153102'
author:
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
- first_name: Aleksandra
full_name: Walczak, Aleksandra
last_name: Walczak
citation:
ama: 'Tkačik G, Walczak A. Information transmission in genetic regulatory networks
a review. Journal of Physics: Condensed Matter. 2011;23(15). doi:10.1088/0953-8984/23/15/153102'
apa: 'Tkačik, G., & Walczak, A. (2011). Information transmission in genetic
regulatory networks a review. Journal of Physics: Condensed Matter. IOP
Publishing Ltd. https://doi.org/10.1088/0953-8984/23/15/153102'
chicago: 'Tkačik, Gašper, and Aleksandra Walczak. “Information Transmission in Genetic
Regulatory Networks a Review.” Journal of Physics: Condensed Matter. IOP
Publishing Ltd., 2011. https://doi.org/10.1088/0953-8984/23/15/153102.'
ieee: 'G. Tkačik and A. Walczak, “Information transmission in genetic regulatory
networks a review,” Journal of Physics: Condensed Matter, vol. 23, no.
15. IOP Publishing Ltd., 2011.'
ista: 'Tkačik G, Walczak A. 2011. Information transmission in genetic regulatory
networks a review. Journal of Physics: Condensed Matter. 23(15), 153102.'
mla: 'Tkačik, Gašper, and Aleksandra Walczak. “Information Transmission in Genetic
Regulatory Networks a Review.” Journal of Physics: Condensed Matter, vol.
23, no. 15, 153102, IOP Publishing Ltd., 2011, doi:10.1088/0953-8984/23/15/153102.'
short: 'G. Tkačik, A. Walczak, Journal of Physics: Condensed Matter 23 (2011).'
date_created: 2018-12-11T12:02:58Z
date_published: 2011-04-01T00:00:00Z
date_updated: 2021-01-12T07:43:03Z
day: '01'
department:
- _id: GaTk
doi: 10.1088/0953-8984/23/15/153102
intvolume: ' 23'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1101.4240
month: '04'
oa: 1
oa_version: Submitted Version
publication: 'Journal of Physics: Condensed Matter'
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '3233'
quality_controlled: '1'
scopus_import: 1
status: public
title: Information transmission in genetic regulatory networks a review
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2011'
...