---
res:
  bibo_abstract:
  - The process of gastrulation is highly conserved across vertebrates on both the
    genetic and morphological levels, despite great variety in embryonic shape and
    speed of development. This mechanism spatially separates the germ layers and establishes
    the organizational foundation for future development. Mesodermal identity is specified
    in a superficial layer of cells, the epiblast, where cells maintain an epithelioid
    morphology. These cells involute to join the deeper hypoblast layer where they
    adopt a migratory, mesenchymal morphology. Expression of a cascade of related
    transcription factors orchestrates the parallel genetic transition from primitive
    to mature mesoderm. Although the early and late stages of this process are increasingly
    well understood, the transition between them has remained largely mysterious.
    We present here the first high resolution in vivo observations of the blebby transitional
    morphology of involuting mesodermal cells in a vertebrate embryo. We further demonstrate
    that the zebrafish spadetail mutation creates a reversible block in the maturation
    program, stalling cells in the transition state. This mutation creates an ideal
    system for dissecting the specific properties of cells undergoing the morphological
    transition of maturing mesoderm, as we demonstrate with a direct measurement of
    cell–cell adhesion.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Richard
      foaf_name: Row, Richard
      foaf_surname: Row
  - foaf_Person:
      foaf_givenName: Jean-Léon
      foaf_name: Maître, Jean-Léon
      foaf_surname: Maître
      foaf_workInfoHomepage: http://www.librecat.org/personId=48F1E0D8-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-3688-1474
  - foaf_Person:
      foaf_givenName: Benjamin
      foaf_name: Martin, Benjamin
      foaf_surname: Martin
  - foaf_Person:
      foaf_givenName: Petra
      foaf_name: Stockinger, Petra
      foaf_surname: Stockinger
      foaf_workInfoHomepage: http://www.librecat.org/personId=261CB030-E90D-11E9-B182-F697D44B663C
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Kimelman, David
      foaf_surname: Kimelman
  bibo_doi: 10.1016/j.ydbio.2011.03.025
  bibo_issue: '1'
  bibo_volume: 354
  dct_date: 2011^xs_gYear
  dct_identifier:
  - UT:000290550500010
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Completion of the epithelial to mesenchymal transition in zebrafish mesoderm
    requires Spadetail@
  fabio_hasPubmedId: '21463614'
...