--- res: bibo_abstract: - Linkage between markers and genes that affect a phenotype of interest may be determined by examining differences in marker allele frequency in the extreme progeny of a cross between two inbred lines. This strategy is usually employed when pooling is used to reduce genotyping costs. When the cross progeny are asexual, the extreme progeny may be selected by multiple generations of asexual reproduction and selection. We analyse this method of measuring phenotype in asexual progeny and examine the changes in marker allele frequency due to selection over many generations. Stochasticity in marker frequency in the selected population arises due to the finite initial population size. We derive the distribution of marker frequency as a result of selection at a single major locus, and show that in order to avoid spurious changes in marker allele frequency in the selected population, the initial population size should be in the low to mid hundreds.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Sayanthan foaf_name: Logeswaran, Sayanthan foaf_surname: Logeswaran - foaf_Person: foaf_givenName: Nicholas H foaf_name: Barton, Nicholas H foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 bibo_doi: 10.1017/S0016672311000115 bibo_issue: '3' bibo_volume: 93 dct_date: 2011^xs_gYear dct_language: eng dct_publisher: Cambridge University Press@ dct_title: Mapping Mendelian traits in asexual progeny using changes in marker allele frequency@ ...