---
_id: '3380'
abstract:
- lang: eng
  text: Linkage between markers and genes that affect a phenotype of interest may
    be determined by examining differences in marker allele frequency in the extreme
    progeny of a cross between two inbred lines. This strategy is usually employed
    when pooling is used to reduce genotyping costs. When the cross progeny are asexual,
    the extreme progeny may be selected by multiple generations of asexual reproduction
    and selection. We analyse this method of measuring phenotype in asexual progeny
    and examine the changes in marker allele frequency due to selection over many
    generations. Stochasticity in marker frequency in the selected population arises
    due to the finite initial population size. We derive the distribution of marker
    frequency as a result of selection at a single major locus, and show that in order
    to avoid spurious changes in marker allele frequency in the selected population,
    the initial population size should be in the low to mid hundreds.
article_processing_charge: No
article_type: original
author:
- first_name: Sayanthan
  full_name: Logeswaran, Sayanthan
  last_name: Logeswaran
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Logeswaran S, Barton NH. Mapping Mendelian traits in asexual progeny using
    changes in marker allele frequency. <i>Genetical Research</i>. 2011;93(3):221-232.
    doi:<a href="https://doi.org/10.1017/S0016672311000115">10.1017/S0016672311000115</a>
  apa: Logeswaran, S., &#38; Barton, N. H. (2011). Mapping Mendelian traits in asexual
    progeny using changes in marker allele frequency. <i>Genetical Research</i>. Cambridge
    University Press. <a href="https://doi.org/10.1017/S0016672311000115">https://doi.org/10.1017/S0016672311000115</a>
  chicago: Logeswaran, Sayanthan, and Nicholas H Barton. “Mapping Mendelian Traits
    in Asexual Progeny Using Changes in Marker Allele Frequency.” <i>Genetical Research</i>.
    Cambridge University Press, 2011. <a href="https://doi.org/10.1017/S0016672311000115">https://doi.org/10.1017/S0016672311000115</a>.
  ieee: S. Logeswaran and N. H. Barton, “Mapping Mendelian traits in asexual progeny
    using changes in marker allele frequency,” <i>Genetical Research</i>, vol. 93,
    no. 3. Cambridge University Press, pp. 221–232, 2011.
  ista: Logeswaran S, Barton NH. 2011. Mapping Mendelian traits in asexual progeny
    using changes in marker allele frequency. Genetical Research. 93(3), 221–232.
  mla: Logeswaran, Sayanthan, and Nicholas H. Barton. “Mapping Mendelian Traits in
    Asexual Progeny Using Changes in Marker Allele Frequency.” <i>Genetical Research</i>,
    vol. 93, no. 3, Cambridge University Press, 2011, pp. 221–32, doi:<a href="https://doi.org/10.1017/S0016672311000115">10.1017/S0016672311000115</a>.
  short: S. Logeswaran, N.H. Barton, Genetical Research 93 (2011) 221–232.
date_created: 2018-12-11T12:03:00Z
date_published: 2011-05-18T00:00:00Z
date_updated: 2025-09-30T08:49:38Z
day: '18'
department:
- _id: NiBa
doi: 10.1017/S0016672311000115
external_id:
  isi:
  - '000291114300005'
intvolume: '        93'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.pure.ed.ac.uk/ws/files/8144621/GR_2011_Barton.pdf
month: '05'
oa: 1
oa_version: Published Version
page: 221 - 232
publication: Genetical Research
publication_status: published
publisher: Cambridge University Press
publist_id: '3227'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mapping Mendelian traits in asexual progeny using changes in marker allele
  frequency
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 93
year: '2011'
...