---
res:
  bibo_abstract:
  - Membrane proteins are involved in essential biological processes such as energy
    conversion, signal transduction, solute transport and secretion. All biological
    processes, also those involving membrane proteins, are steered by molecular interactions.
    Molecular interactions guide the folding and stability of membrane proteins, determine
    their assembly, switch their functional states or mediate signal transduction.
    The sequential steps of molecular interactions driving these processes can be
    described by dynamic energy landscapes. The conceptual energy landscape allows
    to follow the complex reaction pathways of membrane proteins while its modifications
    describe why and how pathways are changed. Single-molecule force spectroscopy
    (SMFS) detects, quantifies and locates interactions within and between membrane
    proteins. SMFS helps to determine how these interactions change with temperature,
    point mutations, oligomerization and the functional states of membrane proteins.
    Applied in different modes, SMFS explores the co-existence and population of reaction
    pathways in the energy landscape of the protein and thus reveals detailed insights
    into local mechanisms, determining its structural and functional relationships.
    Here we review how SMFS extracts the defining parameters of an energy landscape
    such as the barrier position, reaction kinetics and roughness with high precision.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Harald L
      foaf_name: Harald Janovjak
      foaf_surname: Janovjak
      foaf_workInfoHomepage: http://www.librecat.org/personId=33BA6C30-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8023-9315
  - foaf_Person:
      foaf_givenName: Tanuj
      foaf_name: Sapra, Tanuj K
      foaf_surname: Sapra
  - foaf_Person:
      foaf_givenName: Alexej
      foaf_name: Kedrov, Alexej
      foaf_surname: Kedrov
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Mueller, Daniel J
      foaf_surname: Mueller
  bibo_doi: 10.1002/cphc.200700662
  bibo_issue: '7'
  bibo_volume: 9
  dct_date: 2008^xs_gYear
  dct_publisher: Wiley-Blackwell@
  dct_title: 'From valleys to ridges: Exploring the energy landscape of single membrane
    proteins@'
...