--- res: bibo_abstract: - "We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis where morphogens undergo repeated rounds of internalization into cells and recycling. Based on a description on the cellular scale, we derive effective nonlinear transport equations in one and two dimensions which are valid on larger scales. We derive analytic expressions for the concentration dependence of the effective diffusion coefficient and the effective degradation rate. We discuss the effects of a directional bias on morphogen transport and those of the coupling of the morphogen and receptor kinetics. Furthermore, we discuss general properties of cellular transport processes such as the robustness of gradients and relate our results to recent experiments on the morphogen Decapentaplegic (Dpp) that acts in the wing disk of the fruit fly Drosophila.\r\n© 2007 The American Physical Society@eng" bibo_authorlist: - foaf_Person: foaf_givenName: Mark Tobias foaf_name: Bollenbach, Mark Tobias foaf_surname: Bollenbach foaf_workInfoHomepage: http://www.librecat.org/personId=3E6DB97A-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-4398-476X - foaf_Person: foaf_givenName: Karsten foaf_name: Kruse, Karsten foaf_surname: Kruse - foaf_Person: foaf_givenName: Periklis foaf_name: Pantazis, Periklis foaf_surname: Pantazis - foaf_Person: foaf_givenName: Marcos foaf_name: Gonzalez Gaitan, Marcos foaf_surname: Gonzalez Gaitan - foaf_Person: foaf_givenName: Frank foaf_name: Julicher, Frank foaf_surname: Julicher bibo_doi: 10.1103/PhysRevE.75.011901 bibo_issue: '1' bibo_volume: 75 dct_date: 2007^xs_gYear dct_language: eng dct_publisher: American Institute of Physics@ dct_title: Morphogen transport in epithelia@ ...