---
_id: '3427'
abstract:
- lang: eng
  text: "We present a general theoretical framework to discuss mechanisms of morphogen
    transport and gradient formation in a cell layer. Trafficking events on the cellular
    scale lead to transport on larger scales. We discuss in particular the case of
    transcytosis where morphogens undergo repeated rounds of internalization into
    cells and recycling. Based on a description on the cellular scale, we derive effective
    nonlinear transport equations in one and two dimensions which are valid on larger
    scales. We derive analytic expressions for the concentration dependence of the
    effective diffusion coefficient and the effective degradation rate. We discuss
    the effects of a directional bias on morphogen transport and those of the coupling
    of the morphogen and receptor kinetics. Furthermore, we discuss general properties
    of cellular transport processes such as the robustness of gradients and relate
    our results to recent experiments on the morphogen Decapentaplegic (Dpp) that
    acts in the wing disk of the fruit fly Drosophila.\r\n© 2007 The American Physical
    Society"
article_processing_charge: No
arxiv: 1
author:
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Karsten
  full_name: Kruse, Karsten
  last_name: Kruse
- first_name: Periklis
  full_name: Pantazis, Periklis
  last_name: Pantazis
- first_name: Marcos
  full_name: Gonzalez Gaitan, Marcos
  last_name: Gonzalez Gaitan
- first_name: Frank
  full_name: Julicher, Frank
  last_name: Julicher
citation:
  ama: Bollenbach MT, Kruse K, Pantazis P, Gonzalez Gaitan M, Julicher F. Morphogen
    transport in epithelia. <i>Physical Review E Statistical Nonlinear and Soft Matter
    Physics</i>. 2007;75(1). doi:<a href="https://doi.org/10.1103/PhysRevE.75.011901">10.1103/PhysRevE.75.011901</a>
  apa: Bollenbach, M. T., Kruse, K., Pantazis, P., Gonzalez Gaitan, M., &#38; Julicher,
    F. (2007). Morphogen transport in epithelia. <i>Physical Review E Statistical
    Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href="https://doi.org/10.1103/PhysRevE.75.011901">https://doi.org/10.1103/PhysRevE.75.011901</a>
  chicago: Bollenbach, Mark Tobias, Karsten Kruse, Periklis Pantazis, Marcos Gonzalez
    Gaitan, and Frank Julicher. “Morphogen Transport in Epithelia.” <i>Physical Review
    E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics,
    2007. <a href="https://doi.org/10.1103/PhysRevE.75.011901">https://doi.org/10.1103/PhysRevE.75.011901</a>.
  ieee: M. T. Bollenbach, K. Kruse, P. Pantazis, M. Gonzalez Gaitan, and F. Julicher,
    “Morphogen transport in epithelia,” <i>Physical Review E Statistical Nonlinear
    and Soft Matter Physics</i>, vol. 75, no. 1. American Institute of Physics, 2007.
  ista: Bollenbach MT, Kruse K, Pantazis P, Gonzalez Gaitan M, Julicher F. 2007. Morphogen
    transport in epithelia. Physical Review E Statistical Nonlinear and Soft Matter
    Physics. 75(1).
  mla: Bollenbach, Mark Tobias, et al. “Morphogen Transport in Epithelia.” <i>Physical
    Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 75, no. 1, American
    Institute of Physics, 2007, doi:<a href="https://doi.org/10.1103/PhysRevE.75.011901">10.1103/PhysRevE.75.011901</a>.
  short: M.T. Bollenbach, K. Kruse, P. Pantazis, M. Gonzalez Gaitan, F. Julicher,
    Physical Review E Statistical Nonlinear and Soft Matter Physics 75 (2007).
date_created: 2018-12-11T12:03:16Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:43:24Z
day: '01'
doi: 10.1103/PhysRevE.75.011901
extern: '1'
external_id:
  arxiv:
  - q-bio/0609011v1
intvolume: '        75'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/q-bio/0609011v1
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review E Statistical Nonlinear and Soft Matter Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '2974'
status: public
title: Morphogen transport in epithelia
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 75
year: '2007'
...