book chapter published yes Peter M Jonas author 353C1B58-F248-11E8-B48F-1D18A9856A870000-0001-5001-4804 BertSakmann editor ErwinNeher editor At a synapse, the transmitter is stored in synaptic vesicles and is released into the synaptic cleft almost instantaneously upon fusion of these vesicles with the presynaptic membrane. Subsequently, the transmitter diffuses to ligand-gated ion channels in the postsynaptic density, binds to them, and thereby causes channel activation. Unfortunately, we have estimates neither of the exact amount of transmitter in the synaptic vesicle nor of the concentration in the synaptic cleft reaching the postsynaptic receptors, and in some cases even the identity of the transmitter is unknown. These questions may be addressed by modeling of release and diffusion. Such a theoretical approach, however, is based on several assumptions, some of which lack experimental evidence. Plenum1995 eng 978-0-306-44870-610.1007/978-1-4419-1229-9_10 231 - 243 yes Jonas, P. M. (1995). Fast application of agonists to isolated membrane patches. In B. Sakmann &#38; E. Neher (Eds.), <i>Single-channel recording</i> (pp. 231–243). Plenum. <a href="https://doi.org/10.1007/978-1-4419-1229-9_10">https://doi.org/10.1007/978-1-4419-1229-9_10</a> Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.” <i>Single-Channel Recording</i>, edited by Bert Sakmann and Erwin Neher, Plenum, 1995, pp. 231–43, doi:<a href="https://doi.org/10.1007/978-1-4419-1229-9_10">10.1007/978-1-4419-1229-9_10</a>. P. M. Jonas, “Fast application of agonists to isolated membrane patches,” in <i>Single-channel recording</i>, B. Sakmann and E. Neher, Eds. Plenum, 1995, pp. 231–243. Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.” In <i>Single-Channel Recording</i>, edited by Bert Sakmann and Erwin Neher, 231–43. Plenum, 1995. <a href="https://doi.org/10.1007/978-1-4419-1229-9_10">https://doi.org/10.1007/978-1-4419-1229-9_10</a>. P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording, Plenum, 1995, pp. 231–243. Jonas PM. 1995.Fast application of agonists to isolated membrane patches. In: Single-channel recording. , 231–243. Jonas PM. Fast application of agonists to isolated membrane patches. In: Sakmann B, Neher E, eds. <i>Single-Channel Recording</i>. Plenum; 1995:231-243. doi:<a href="https://doi.org/10.1007/978-1-4419-1229-9_10">10.1007/978-1-4419-1229-9_10</a> 34552018-12-11T12:03:25Z2022-06-28T08:51:40Z