---
_id: '3455'
abstract:
- lang: eng
  text: At a synapse, the transmitter is stored in synaptic vesicles and is released
    into the synaptic cleft almost instantaneously upon fusion of these vesicles with
    the presynaptic membrane. Subsequently, the transmitter diffuses to ligand-gated
    ion channels in the postsynaptic density, binds to them, and thereby causes channel
    activation. Unfortunately, we have estimates neither of the exact amount of transmitter
    in the synaptic vesicle nor of the concentration in the synaptic cleft reaching
    the postsynaptic receptors, and in some cases even the identity of the transmitter
    is unknown. These questions may be addressed by modeling of release and diffusion.
    Such a theoretical approach, however, is based on several assumptions, some of
    which lack experimental evidence.
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Jonas PM. Fast application of agonists to isolated membrane patches. In: Sakmann
    B, Neher E, eds. <i>Single-Channel Recording</i>. Plenum; 1995:231-243. doi:<a
    href="https://doi.org/10.1007/978-1-4419-1229-9_10">10.1007/978-1-4419-1229-9_10</a>'
  apa: Jonas, P. M. (1995). Fast application of agonists to isolated membrane patches.
    In B. Sakmann &#38; E. Neher (Eds.), <i>Single-channel recording</i> (pp. 231–243).
    Plenum. <a href="https://doi.org/10.1007/978-1-4419-1229-9_10">https://doi.org/10.1007/978-1-4419-1229-9_10</a>
  chicago: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
    In <i>Single-Channel Recording</i>, edited by Bert Sakmann and Erwin Neher, 231–43.
    Plenum, 1995. <a href="https://doi.org/10.1007/978-1-4419-1229-9_10">https://doi.org/10.1007/978-1-4419-1229-9_10</a>.
  ieee: P. M. Jonas, “Fast application of agonists to isolated membrane patches,”
    in <i>Single-channel recording</i>, B. Sakmann and E. Neher, Eds. Plenum, 1995,
    pp. 231–243.
  ista: 'Jonas PM. 1995.Fast application of agonists to isolated membrane patches.
    In: Single-channel recording. , 231–243.'
  mla: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
    <i>Single-Channel Recording</i>, edited by Bert Sakmann and Erwin Neher, Plenum,
    1995, pp. 231–43, doi:<a href="https://doi.org/10.1007/978-1-4419-1229-9_10">10.1007/978-1-4419-1229-9_10</a>.
  short: P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording, Plenum,
    1995, pp. 231–243.
date_created: 2018-12-11T12:03:25Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T08:51:40Z
day: '01'
doi: 10.1007/978-1-4419-1229-9_10
editor:
- first_name: Bert
  full_name: Sakmann, Bert
  last_name: Sakmann
- first_name: Erwin
  full_name: Neher, Erwin
  last_name: Neher
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4419-1229-9_10
month: '01'
oa_version: None
page: 231 - 243
publication: Single-channel recording
publication_identifier:
  isbn:
  - 978-0-306-44870-6
publication_status: published
publisher: Plenum
publist_id: '2932'
quality_controlled: '1'
status: public
title: Fast application of agonists to isolated membrane patches
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...