--- _id: '3456' abstract: - lang: eng text: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric proteins, probably tetramers, formed by a variety of molecularly distinct subunits. AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and -D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional molecular diversity of AMPARs is generated by alternative splicing of the flip-flop module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants have been identified for the NR1 subunit, and a new NR3 subunit has been discovered recently. Considering all combinatorial possibilities, the molecular diversity of glutamate-receptor channels is considerable (HOLLMANN, this volume). alternative_title: - Handbook of experimental pharmacology article_processing_charge: No author: - first_name: Hannah full_name: Monyer, Hannah last_name: Monyer - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Jean full_name: Rossier, Jean last_name: Rossier citation: ama: 'Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H, eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339. doi:10.1007/978-3-662-08022-1_9' apa: Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9 chicago: Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.” In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9. ieee: H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds. Springer, 1999, pp. 309–339. ista: 'Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.' mla: Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer, 1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9. short: H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339. date_created: 2018-12-11T12:03:25Z date_published: 1999-01-01T00:00:00Z date_updated: 2022-09-07T13:30:23Z day: '01' doi: 10.1007/978-3-662-08022-1_9 editor: - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Hannah full_name: Monyer, Hannah last_name: Monyer extern: '1' intvolume: ' 141' language: - iso: eng month: '01' oa_version: None page: 309 - 339 publication: Ionotropic Glutamate Receptors in the CNS publication_identifier: isbn: - '9783642085390' publication_status: published publisher: Springer publist_id: '2931' quality_controlled: '1' scopus_import: '1' status: public title: Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS type: book_chapter user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 141 year: '1999' ...