---
_id: '3456'
abstract:
- lang: eng
text: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and
N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic
glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the
mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric
proteins, probably tetramers, formed by a variety of molecularly distinct subunits.
AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and
-D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional
molecular diversity of AMPARs is generated by alternative splicing of the flip-flop
module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily
assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants
have been identified for the NR1 subunit, and a new NR3 subunit has been discovered
recently. Considering all combinatorial possibilities, the molecular diversity
of glutamate-receptor channels is considerable (HOLLMANN, this volume).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Jean
full_name: Rossier, Jean
last_name: Rossier
citation:
ama: 'Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H,
eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339.
doi:10.1007/978-3-662-08022-1_9'
apa: Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants
controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In
P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS
(Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9
chicago: Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants
Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.”
In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and
Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9.
ieee: H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling
functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic
Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds.
Springer, 1999, pp. 309–339.
ista: 'Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate
Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.'
mla: Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties
of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors
in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer,
1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9.
short: H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic
Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339.
date_created: 2018-12-11T12:03:25Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:30:23Z
day: '01'
doi: 10.1007/978-3-662-08022-1_9
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 309 - 339
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular determinants controlling functional properties of AMPARs and NMDARs
in the mammalian CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...