---
_id: '3460'
abstract:
- lang: eng
text: Excitatory postsynaptic currents in neurones of the central nervous system
have a dual-component time course that results from the co-activation of AMPA/kainate-type
and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular
biology have provided a better understanding of the factors that determine the
kinectics of excitatory postsynaptic currents. Recent studies suggest that the
time course of neurotransmitter concentration in the synaptic cleft, the gating
properties of the native channels, and the glutamate receptor subunit composition
all appear to be important factors.
acknowledgement: 'We thank JGG Borst, N Burnashev, M Häusser, G Stuart and A Viilarroel
for critically reading the manuscript and E von Kitzing and A Roth for doing the
simulations and for many helpful discussions. Supported by the Deutsche Forschungsgemeinschaft
(SFB 317-B14) and the Alexander von Humboldt Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Nelson
full_name: Spruston, Nelson
last_name: Spruston
citation:
ama: Jonas PM, Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic
currents in the CNS. Current Opinion in Neurobiology. 1994;4(3):366-372.
doi:10.1016/0959-4388(94)90098-1
apa: Jonas, P. M., & Spruston, N. (1994). Mechanisms shaping glutamate-mediated
excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology.
Elsevier. https://doi.org/10.1016/0959-4388(94)90098-1
chicago: Jonas, Peter M, and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology.
Elsevier, 1994. https://doi.org/10.1016/0959-4388(94)90098-1.
ieee: P. M. Jonas and N. Spruston, “Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS,” Current Opinion in Neurobiology, vol.
4, no. 3. Elsevier, pp. 366–372, 1994.
ista: Jonas PM, Spruston N. 1994. Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS. Current Opinion in Neurobiology. 4(3), 366–372.
mla: Jonas, Peter M., and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology,
vol. 4, no. 3, Elsevier, 1994, pp. 366–72, doi:10.1016/0959-4388(94)90098-1.
short: P.M. Jonas, N. Spruston, Current Opinion in Neurobiology 4 (1994) 366–372.
date_created: 2018-12-11T12:03:27Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-03T11:26:52Z
day: '01'
doi: 10.1016/0959-4388(94)90098-1
extern: '1'
external_id:
pmid:
- '7522678 '
intvolume: ' 4'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0959438894900981?via%3Dihub
month: '06'
oa_version: None
page: 366 - 372
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '2927'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the
CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '1994'
...