--- _id: '3460' abstract: - lang: eng text: Excitatory postsynaptic currents in neurones of the central nervous system have a dual-component time course that results from the co-activation of AMPA/kainate-type and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular biology have provided a better understanding of the factors that determine the kinectics of excitatory postsynaptic currents. Recent studies suggest that the time course of neurotransmitter concentration in the synaptic cleft, the gating properties of the native channels, and the glutamate receptor subunit composition all appear to be important factors. acknowledgement: 'We thank JGG Borst, N Burnashev, M Häusser, G Stuart and A Viilarroel for critically reading the manuscript and E von Kitzing and A Roth for doing the simulations and for many helpful discussions. Supported by the Deutsche Forschungsgemeinschaft (SFB 317-B14) and the Alexander von Humboldt Foundation. ' article_processing_charge: No article_type: original author: - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Nelson full_name: Spruston, Nelson last_name: Spruston citation: ama: Jonas PM, Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology. 1994;4(3):366-372. doi:10.1016/0959-4388(94)90098-1 apa: Jonas, P. M., & Spruston, N. (1994). Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/0959-4388(94)90098-1 chicago: Jonas, Peter M, and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology. Elsevier, 1994. https://doi.org/10.1016/0959-4388(94)90098-1. ieee: P. M. Jonas and N. Spruston, “Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS,” Current Opinion in Neurobiology, vol. 4, no. 3. Elsevier, pp. 366–372, 1994. ista: Jonas PM, Spruston N. 1994. Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology. 4(3), 366–372. mla: Jonas, Peter M., and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology, vol. 4, no. 3, Elsevier, 1994, pp. 366–72, doi:10.1016/0959-4388(94)90098-1. short: P.M. Jonas, N. Spruston, Current Opinion in Neurobiology 4 (1994) 366–372. date_created: 2018-12-11T12:03:27Z date_published: 1994-06-01T00:00:00Z date_updated: 2022-06-03T11:26:52Z day: '01' doi: 10.1016/0959-4388(94)90098-1 extern: '1' external_id: pmid: - '7522678 ' intvolume: ' 4' issue: '3' language: - iso: eng main_file_link: - url: https://www.sciencedirect.com/science/article/pii/0959438894900981?via%3Dihub month: '06' oa_version: None page: 366 - 372 pmid: 1 publication: Current Opinion in Neurobiology publication_identifier: issn: - 0959-4388 publication_status: published publisher: Elsevier publist_id: '2927' quality_controlled: '1' scopus_import: '1' status: public title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 4 year: '1994' ...