Temperature dependence of gating current in myelinated nerve fibers Jonas, Peter M ; https://orcid.org/0000-0001-5001-4804 Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states. Springer 1989 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/3465 Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. <i>Journal of Membrane Biology</i>. 1989;112(3):277-289. doi:<a href="https://doi.org/10.1007/BF01870958">10.1007/BF01870958</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1007/BF01870958 info:eu-repo/semantics/altIdentifier/issn/0022-2631 info:eu-repo/semantics/altIdentifier/e-issn/1432-1424 info:eu-repo/semantics/altIdentifier/pmid/2559205 info:eu-repo/semantics/closedAccess