{"abstract":[{"text":"Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states.","lang":"eng"}],"citation":{"ama":"Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. <i>Journal of Membrane Biology</i>. 1989;112(3):277-289. doi:<a href=\"https://doi.org/10.1007/BF01870958\">10.1007/BF01870958</a>","ista":"Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 112(3), 277–289.","short":"P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289.","apa":"Jonas, P. M. (1989). Temperature dependence of gating current in myelinated nerve fibers. <i>Journal of Membrane Biology</i>. Springer. <a href=\"https://doi.org/10.1007/BF01870958\">https://doi.org/10.1007/BF01870958</a>","mla":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” <i>Journal of Membrane Biology</i>, vol. 112, no. 3, Springer, 1989, pp. 277–89, doi:<a href=\"https://doi.org/10.1007/BF01870958\">10.1007/BF01870958</a>.","chicago":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” <i>Journal of Membrane Biology</i>. Springer, 1989. <a href=\"https://doi.org/10.1007/BF01870958\">https://doi.org/10.1007/BF01870958</a>.","ieee":"P. M. Jonas, “Temperature dependence of gating current in myelinated nerve fibers,” <i>Journal of Membrane Biology</i>, vol. 112, no. 3. Springer, pp. 277–289, 1989."},"publisher":"Springer","publication":"Journal of Membrane Biology","volume":112,"issue":"3","pmid":1,"article_type":"original","title":"Temperature dependence of gating current in myelinated nerve fibers","date_updated":"2022-02-15T08:59:02Z","quality_controlled":"1","status":"public","day":"01","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF01870958"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","external_id":{"pmid":["2559205 "]},"author":[{"full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","first_name":"Peter M","last_name":"Jonas"}],"oa_version":"None","intvolume":"       112","_id":"3465","type":"journal_article","extern":"1","publist_id":"2922","date_published":"1989-12-01T00:00:00Z","month":"12","year":"1989","scopus_import":"1","article_processing_charge":"No","publication_identifier":{"eissn":["1432-1424"],"issn":["0022-2631"]},"language":[{"iso":"eng"}],"doi":"10.1007/BF01870958","date_created":"2018-12-11T12:03:28Z","page":"277 - 289"}