{"intvolume":" 112","volume":112,"quality_controlled":"1","doi":"10.1007/BF01870958","article_processing_charge":"No","type":"journal_article","_id":"3465","page":"277 - 289","external_id":{"pmid":["2559205 "]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"1989","publist_id":"2922","publisher":"Springer","day":"01","month":"12","status":"public","publication_status":"published","article_type":"original","title":"Temperature dependence of gating current in myelinated nerve fibers","pmid":1,"language":[{"iso":"eng"}],"date_updated":"2022-02-15T08:59:02Z","date_created":"2018-12-11T12:03:28Z","author":[{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF01870958"}],"publication":"Journal of Membrane Biology","publication_identifier":{"eissn":["1432-1424"],"issn":["0022-2631"]},"citation":{"ama":"Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 1989;112(3):277-289. doi:10.1007/BF01870958","ista":"Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 112(3), 277–289.","ieee":"P. M. Jonas, “Temperature dependence of gating current in myelinated nerve fibers,” Journal of Membrane Biology, vol. 112, no. 3. Springer, pp. 277–289, 1989.","short":"P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289.","apa":"Jonas, P. M. (1989). Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. Springer. https://doi.org/10.1007/BF01870958","mla":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology, vol. 112, no. 3, Springer, 1989, pp. 277–89, doi:10.1007/BF01870958.","chicago":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology. Springer, 1989. https://doi.org/10.1007/BF01870958."},"abstract":[{"text":"Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states.","lang":"eng"}],"extern":"1","issue":"3","oa_version":"None","scopus_import":"1","date_published":"1989-12-01T00:00:00Z"}