ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability Jonas, Peter M ; https://orcid.org/0000-0001-5001-4804 Koh, Duk Kampe, Knut Hermsteiner, Markus Vogel, Werner Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions. Springer 1991 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/3468 Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. <i>Pflügers Archiv : European Journal of Physiology</i>. 1991;418(1-2):68-73. doi:<a href="https://doi.org/10.1007/BF00370453">10.1007/BF00370453</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1007/BF00370453 info:eu-repo/semantics/altIdentifier/issn/0031-6768 info:eu-repo/semantics/altIdentifier/e-issn/1432-2013 info:eu-repo/semantics/altIdentifier/pmid/2041727 info:eu-repo/semantics/closedAccess