{"date_updated":"2022-03-03T14:42:06Z","quality_controlled":"1","month":"01","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","oa_version":"None","abstract":[{"text":"Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions.\r\n","lang":"eng"}],"date_published":"1991-01-01T00:00:00Z","citation":{"mla":"Jonas, Peter M., et al. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” <i>Pflügers Archiv : European Journal of Physiology</i>, vol. 418, no. 1–2, Springer, 1991, pp. 68–73, doi:<a href=\"https://doi.org/10.1007/BF00370453\">10.1007/BF00370453</a>.","ama":"Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. <i>Pflügers Archiv : European Journal of Physiology</i>. 1991;418(1-2):68-73. doi:<a href=\"https://doi.org/10.1007/BF00370453\">10.1007/BF00370453</a>","chicago":"Jonas, Peter M, Duk Koh, Knut Kampe, Markus Hermsteiner, and Werner Vogel. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” <i>Pflügers Archiv : European Journal of Physiology</i>. Springer, 1991. <a href=\"https://doi.org/10.1007/BF00370453\">https://doi.org/10.1007/BF00370453</a>.","short":"P.M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, W. Vogel, Pflügers Archiv : European Journal of Physiology 418 (1991) 68–73.","apa":"Jonas, P. M., Koh, D., Kampe, K., Hermsteiner, M., &#38; Vogel, W. (1991). ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. <i>Pflügers Archiv : European Journal of Physiology</i>. Springer. <a href=\"https://doi.org/10.1007/BF00370453\">https://doi.org/10.1007/BF00370453</a>","ieee":"P. M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, and W. Vogel, “ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability,” <i>Pflügers Archiv : European Journal of Physiology</i>, vol. 418, no. 1–2. Springer, pp. 68–73, 1991.","ista":"Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. 1991. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. Pflügers Archiv : European Journal of Physiology. 418(1–2), 68–73."},"main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF00370453"}],"type":"journal_article","volume":418,"publication_identifier":{"issn":["0031-6768"],"eissn":["1432-2013"]},"year":"1991","article_processing_charge":"No","issue":"1-2","external_id":{"pmid":["2041727"]},"publist_id":"2919","page":"68 - 73","doi":"10.1007/BF00370453","extern":"1","language":[{"iso":"eng"}],"_id":"3468","scopus_import":"1","status":"public","date_created":"2018-12-11T12:03:29Z","publication":"Pflügers Archiv : European Journal of Physiology","author":[{"full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"},{"first_name":"Duk","full_name":"Koh, Duk","last_name":"Koh"},{"full_name":"Kampe, Knut","first_name":"Knut","last_name":"Kampe"},{"last_name":"Hermsteiner","full_name":"Hermsteiner, Markus","first_name":"Markus"},{"full_name":"Vogel, Werner","first_name":"Werner","last_name":"Vogel"}],"title":"ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability","pmid":1,"publisher":"Springer","intvolume":"       418","article_type":"original"}