article published yes Peter M Jonas author 353C1B58-F248-11E8-B48F-1D18A9856A870000-0001-5001-4804 Duk Koh author Knut Kampe author Markus Hermsteiner author Werner Vogel author Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions. Springer1991 eng 0031-6768 1432-2013 204172710.1007/BF00370453 4181-268 - 73 yes Jonas, P. M., Koh, D., Kampe, K., Hermsteiner, M., &#38; Vogel, W. (1991). ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. <i>Pflügers Archiv : European Journal of Physiology</i>. Springer. <a href="https://doi.org/10.1007/BF00370453">https://doi.org/10.1007/BF00370453</a> Jonas, Peter M, Duk Koh, Knut Kampe, Markus Hermsteiner, and Werner Vogel. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” <i>Pflügers Archiv : European Journal of Physiology</i>. Springer, 1991. <a href="https://doi.org/10.1007/BF00370453">https://doi.org/10.1007/BF00370453</a>. P.M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, W. Vogel, Pflügers Archiv : European Journal of Physiology 418 (1991) 68–73. P. M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, and W. Vogel, “ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability,” <i>Pflügers Archiv : European Journal of Physiology</i>, vol. 418, no. 1–2. Springer, pp. 68–73, 1991. Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. <i>Pflügers Archiv : European Journal of Physiology</i>. 1991;418(1-2):68-73. doi:<a href="https://doi.org/10.1007/BF00370453">10.1007/BF00370453</a> Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. 1991. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. Pflügers Archiv : European Journal of Physiology. 418(1–2), 68–73. Jonas, Peter M., et al. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” <i>Pflügers Archiv : European Journal of Physiology</i>, vol. 418, no. 1–2, Springer, 1991, pp. 68–73, doi:<a href="https://doi.org/10.1007/BF00370453">10.1007/BF00370453</a>. 34682018-12-11T12:03:29Z2022-03-03T14:42:06Z