---
res:
  bibo_abstract:
  - 1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate
    gyrus of rat hippocampal slices. Basket cells were identified by their location,
    dendritic morphology and high frequency of action potentials generated during
    sustained current injection. 2. Dual-component currents were activated by fast
    application of glutamate to outside-out membrane patches isolated from basket
    cell somata (10 μM glycine, no external Mg2+). The fast component was selectively
    blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), the slow component by
    D-2-amino-5-phosphonopentanoic acid (D-AP5). This suggests that the two components
    were mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR)/kainate
    receptor and N-methyl-D-aspartate receptor (NMDAR) channels, respectively. The
    mean ratio of the peak current of the NMDAR component to that of the AMPAR/kainate
    receptor component was 0.22 (1 ms pulses of 10 mM glutamate). 3. The AMPAR/kainate
    receptor component, which was studied in isolation in the presence of D-AP5, was
    identified as AMPAR mediated on the basis of the preferential activation by AMPA
    as compared with kainate, the weak desensitization of kainate-activated currents,
    the cross-desensitization between AMPA and kainate, and the reduction of desensitization
    by cyclothiazide. 4. Deactivation of basket cell AMPARs following 1 ms pulses
    of glutamate occurred with a time constant (τ) of 1.2 ± 0.1 ms (mean ± S.E.M.).
    During 100 ms glutamate pulses, AMPARs desensitized with a τ of 3.7 ± 0.2 ms.
    5. The peak current-voltage (I-V) relation of AMPAR-mediated currents in Na+-rich
    extracellular solution showed a reversal potential of -4.0 ± 2.6 mV and was characterized
    by a doubly rectifying shape. The conductance of single AMPAR channels was estimated
    as 22.6 ± 1.6 pS using non-stationary fluctuation analysis. AMPARs expressed in
    hippocampal basket cells mere highly Ca2+ permeable (P(Ca)/P(K) = 1.79). 6. NMDARs
    in hippocampal basket cells were studied in isolation in the presence of CNQX.
    Deactivation of NMDARs activated by glutamate pulses occurred bi-exponentially
    with mean τ values of 266 ± 23 ms (76%) and 2620 ± 383 ms (24%). 7. The peak I-V
    relation of the NMDAR-mediated component in Na+-rich extracellular solution showed
    a reversal potential of 1.5 ± 0.6 mV and a region of negative slope at negative
    membrane potentials in the presence of external Mg2+, due to voltage-dependent
    block by these ions. The conductance of single NMDAR channels in the main open
    state was 50.2 ± 1.8 pS. NMDARs in hippocampal basket cells were highly permeable
    to Ca2+ (P(Ca)/P(K) = 6.68). 8. AMPARs in hippocampal basket cells are characterized
    by about threefold faster kinetics and twentyfold higher Ca2+ permeability than
    AMPARs in hippocampal granule or pyramidal cells. Simulations show that the Ca2+
    influx through basket cell AMPARs is comparable to that through NMDARs at negative
    membrane potentials with physiological concentrations of Ca2+ and Mg2+. This suggests
    a dual pathway of synaptically mediated Ca2+ entry into interneurones.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Duk
      foaf_name: Koh, Duk
      foaf_surname: Koh
  - foaf_Person:
      foaf_givenName: Jörg
      foaf_name: Geiger, Jörg
      foaf_surname: Geiger
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  - foaf_Person:
      foaf_givenName: Bert
      foaf_name: Sakmann, Bert
      foaf_surname: Sakmann
  bibo_doi: 10.1113/jphysiol.1995.sp020737
  bibo_issue: Pt 2
  bibo_volume: 485
  dct_date: 1995^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0022-3751
  dct_language: eng
  dct_publisher: Wiley-Blackwell@
  dct_title: Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat
    hippocampal dentate gyrus@
  fabio_hasPubmedId: '7545230'
...