{"date_created":"2018-12-11T12:03:35Z","volume":504,"abstract":[{"lang":"eng","text":"1. Dendritic patch-clamp recordings were obtained from mitral cells in rat olfactory bulb slices, up to 350 μm from the soma. Simultaneous dendritic and somatic whole-cell recordings indicated that action potentials (APs) evoked by somatic or dendritic current injection were initiated near the soma. Both the large amplitude (100.7 ± 1.1 mV) and the short duration (1.38 ± 0.07 ms) of the AP were maintained as the AP propagated back into the primary mitral cell dendrites. 2. Outside-out patches isolated from mitral cell dendrites contained voltage-gated Na+ channels (peak conductance density, 90 pS μm-2 at -10 mV). When an AP was used as a somatic voltage-clamp command in the presence of 1 μM tetrodotoxin (TTX), the amplitude of the dendritic potential was attenuated to 48 ± 14 mV. This shows that dendritic Na+ channels support the active back-propagation of APs. 3. Dendritic patches contained voltage-gated K+ channels with high density (conductance density, 513 pS μm-2 at 30 mV. Dendritic K+ currents were reduced to 35% by 1 mM external tetraethylammonium chloride (TEACl). When an AP was used as a somatic voltage clamp command in the presence of TEACl, the dendritic potential was markedly prolonged. This indicates that dendritic K+ channels mediate the fast repolarization of dendritic APs. 4. We conclude that voltage gated Na+ and K+ channels support dendritic APs with large amplitudes and short durations that may trigger fast transmitter release at dendrodendritic synapses in the olfactory bulb."}],"_id":"3486","oa":1,"publication_status":"published","language":[{"iso":"eng"}],"publication":"Journal of Physiology","pmid":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"15","publisher":"Wiley-Blackwell","status":"public","external_id":{"pmid":["9365910"]},"author":[{"first_name":"Joseph","last_name":"Bischofberger","full_name":"Bischofberger, Joseph"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M"}],"oa_version":"Published Version","date_updated":"2022-08-19T12:02:21Z","publist_id":"2901","page":"359 - 365","type":"journal_article","doi":"10.1111/j.1469-7793.1997.359be.x","article_type":"original","issue":"Pt 2","acknowledgement":"We thank Drs J. R. P. Geiger, M. Martina, and D. Schild for critically reading the manuscript, and Mrs B. Plessow-Freudenberg for technical assistance. This work was supported by DFG grant BI 642/1-1 and German Israeli Foundation grant I 0352-073.01/94.","quality_controlled":"1","title":"Action potential propagation into the presynaptic dendrites of rat mitral cells","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159916/"}],"intvolume":"       504","citation":{"chicago":"Bischofberger, Joseph, and Peter M Jonas. “Action Potential Propagation into the Presynaptic Dendrites of Rat Mitral Cells.” <i>Journal of Physiology</i>. Wiley-Blackwell, 1997. <a href=\"https://doi.org/10.1111/j.1469-7793.1997.359be.x\">https://doi.org/10.1111/j.1469-7793.1997.359be.x</a>.","apa":"Bischofberger, J., &#38; Jonas, P. M. (1997). Action potential propagation into the presynaptic dendrites of rat mitral cells. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1469-7793.1997.359be.x\">https://doi.org/10.1111/j.1469-7793.1997.359be.x</a>","ista":"Bischofberger J, Jonas PM. 1997. Action potential propagation into the presynaptic dendrites of rat mitral cells. Journal of Physiology. 504(Pt 2), 359–365.","short":"J. Bischofberger, P.M. Jonas, Journal of Physiology 504 (1997) 359–365.","mla":"Bischofberger, Joseph, and Peter M. Jonas. “Action Potential Propagation into the Presynaptic Dendrites of Rat Mitral Cells.” <i>Journal of Physiology</i>, vol. 504, no. Pt 2, Wiley-Blackwell, 1997, pp. 359–65, doi:<a href=\"https://doi.org/10.1111/j.1469-7793.1997.359be.x\">10.1111/j.1469-7793.1997.359be.x</a>.","ieee":"J. Bischofberger and P. M. Jonas, “Action potential propagation into the presynaptic dendrites of rat mitral cells,” <i>Journal of Physiology</i>, vol. 504, no. Pt 2. Wiley-Blackwell, pp. 359–365, 1997.","ama":"Bischofberger J, Jonas PM. Action potential propagation into the presynaptic dendrites of rat mitral cells. <i>Journal of Physiology</i>. 1997;504(Pt 2):359-365. doi:<a href=\"https://doi.org/10.1111/j.1469-7793.1997.359be.x\">10.1111/j.1469-7793.1997.359be.x</a>"},"extern":"1","date_published":"1997-10-15T00:00:00Z","month":"10","year":"1997","publication_identifier":{"issn":["0022-3751"]}}