---
res:
  bibo_abstract:
  - We have examined gating and pharmacological characteristics of somatic K+ channels
    in fast-spiking interneurons and regularly spiking principal neurons of hippocampal
    slices. In nucleated patches isolated from basket cells of the dentate gyrus,
    a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium
    (TEA) and 4-aminopyridine (4- AP) (half-maximal inhibitory concentrations <0.1
    mM) predominated, contributing an average of 58% to the total K+ current in these
    cells. By contrast, in pyramidal neurons of the CA1 region a rapidly inactivating
    A- type K+ current component that was TEA-resistant prevailed, contributing 61%
    to the total K+ current. Both types of neurons also showed small amounts of the
    K+ current component mainly found in the other type of neuron and, in addition,
    a slow delayed rectifier K+ current component with intermediate properties (sow
    inactivation, intermediate sensitivity to TEA). Single-cell RT-PCR analysis of
    mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were expressed in almost
    all (89%) of the interneurons but only in 17% of the pyramidal neurons. In contrast,
    Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of pyramidal neurons but
    only in 55% of interneurons. Selective block of fast delayed rectifier K+ channels,
    presumably assembled from Kv3 subunits, by 4-AP reduced substantially the action
    potential frequency in interneurons. These results indicate that the differential
    expression of Kv3 and Kv4 subunits shapes the action potential phenotypes of principal
    neurons and interneurons in the cortex.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Marco
      foaf_name: Martina, Marco
      foaf_surname: Martina
  - foaf_Person:
      foaf_givenName: Jobst
      foaf_name: Schultz, Jobst
      foaf_surname: Schultz
  - foaf_Person:
      foaf_givenName: Heimo
      foaf_name: Ehmke, Heimo
      foaf_surname: Ehmke
  - foaf_Person:
      foaf_givenName: Hannah
      foaf_name: Monyer, Hannah
      foaf_surname: Monyer
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1523/JNEUROSCI.18-20-08111.1998
  bibo_issue: '20'
  bibo_volume: 18
  dct_date: 1998^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Functional and molecular differences between voltage-gated K+ channels
    of fast-spiking interneurons and pyramidal neurons of rat hippocampus@
  fabio_hasPubmedId: '9763458'
...