---
res:
  bibo_abstract:
  - We have examined factors that determine the strength and dynamics of GABAergic
    synapses between interneurons [dentate gyrus basket cells (BCs)] and principal
    neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal
    slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular
    Cl− concentration showed a fast rise and a biexponential decay, with mean time
    constants of 2 and 9 msec. The mean quantal conductance change, determined directly
    at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release
    at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis
    of IPSC peak amplitudes and numbers of failures by multiple probability compound
    binomial analysis indicated that synaptic transmission at the BC–GC synapse involves
    three to seven release sites, each of which releases transmitter with high probability
    (∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression
    (PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery
    from depression occurred with a time constant of 2 sec. Paired-pulse depression
    was mainly presynaptic in origin but appeared to be independent of previous release.
    Synaptic transmission at the BC–GC synapse showed frequency-dependent depression,
    with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials.
    The relative stability of transmission at the BC–GC synapse is consistent with
    a model in which an activity-dependent gating mechanism reduces release probability
    and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus
    several mechanisms converge on the generation of powerful and sustained transmission
    at interneuron–principal neuron synapses in hippocampal circuits.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Udo
      foaf_name: Kraushaar, Udo
      foaf_surname: Kraushaar
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1523/JNEUROSCI.20-15-05594.2000
  bibo_issue: '15'
  bibo_volume: 20
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal
    neuron synapse@
  fabio_hasPubmedId: '10908596'
...