---
res:
  bibo_abstract:
  - Long-term depression (LTD) is a form of synaptic plasticity that can be induced
    either by low-frequency stimulation of presynaptic fibers or in an associative
    manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated
    the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus
    using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices.
    Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with
    a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude
    to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant
    to the application of D-AP-5, indicating that it is independent of NMDA receptors.
    In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine,
    indicating the involvement of metabotropic glutamate receptors. Furthermore, associative
    LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic
    action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin
    GVIA, a selective N-type channel blocker, abolished the induction of associative
    LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist,
    inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting
    presynaptic transmitter release. OH-DPAT also inhibited the induction of associative
    LTD, suggesting that the involvement of N-type channels makes synaptic plasticity
    accessible to modulation by neurotransmitters. Thus, the modulation of N-type
    Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal
    neurons.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Claus
      foaf_name: Normann, Claus
      foaf_surname: Normann
  - foaf_Person:
      foaf_givenName: Diana
      foaf_name: Peckys, Diana
      foaf_surname: Peckys
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Schulze, Christian
      foaf_surname: Schulze
  - foaf_Person:
      foaf_givenName: Jörg
      foaf_name: Walden, Jörg
      foaf_surname: Walden
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  - foaf_Person:
      foaf_givenName: Joseph
      foaf_name: Bischofberger, Joseph
      foaf_surname: Bischofberger
  bibo_doi: 10.1523/JNEUROSCI.20-22-08290.2000
  bibo_issue: '22'
  bibo_volume: 20
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Associative long-term depression in the hippocampus is dependent on postsynaptic
    N-type Ca(2+) channels@
  fabio_hasPubmedId: '11069935'
...