---
res:
  bibo_abstract:
  - Mutual synaptic interactions between GABAergic interneurons are thought to be
    of critical importance for the generation of network oscillations and for temporal
    encoding of information in the hippocampus. However, the functional properties
    of synaptic transmission between hippocampal interneurons are largely unknown.
    We have made paired recordings from basket cells (BCs) in the dentate gyrus of
    rat hippocampal slices, followed by correlated light and electron microscopical
    analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the
    soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2
    msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression
    (PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression
    during repetitive stimulation. Detailed passive cable model simulations based
    on somatodendritic morphology and localization of synaptic contacts further indicated
    that the conductance change at the postsynaptic site was even faster, decaying
    with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed
    that the decay time course of IPSCs at BC–BC synapses was approximately twofold
    faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable.
    To examine the consequences of the fast postsynaptic conductance change for the
    generation of oscillatory activity, we developed a computational model of an interneuron
    network. The model showed robust oscillations at frequencies >60 Hz if the
    excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron
    synapses may promote the generation of high-frequency oscillations observed in
    the dentate gyrusin vivo. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Marlene
      foaf_name: Bartos, Marlene
      foaf_surname: Bartos
  - foaf_Person:
      foaf_givenName: Imre
      foaf_name: Vida, Imre
      foaf_surname: Vida
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Frotscher, Michael
      foaf_surname: Frotscher
  - foaf_Person:
      foaf_givenName: Jörg
      foaf_name: Geiger, Jörg
      foaf_surname: Geiger
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1523/JNEUROSCI.21-08-02687.2001
  bibo_issue: '8'
  bibo_volume: 21
  dct_date: 2001^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron
    network.@
  fabio_hasPubmedId: '11306622'
...