---
_id: '3494'
abstract:
- lang: eng
  text: 'Mutual synaptic interactions between GABAergic interneurons are thought to
    be of critical importance for the generation of network oscillations and for temporal
    encoding of information in the hippocampus. However, the functional properties
    of synaptic transmission between hippocampal interneurons are largely unknown.
    We have made paired recordings from basket cells (BCs) in the dentate gyrus of
    rat hippocampal slices, followed by correlated light and electron microscopical
    analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the
    soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2
    msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression
    (PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression
    during repetitive stimulation. Detailed passive cable model simulations based
    on somatodendritic morphology and localization of synaptic contacts further indicated
    that the conductance change at the postsynaptic site was even faster, decaying
    with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed
    that the decay time course of IPSCs at BC–BC synapses was approximately twofold
    faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable.
    To examine the consequences of the fast postsynaptic conductance change for the
    generation of oscillatory activity, we developed a computational model of an interneuron
    network. The model showed robust oscillations at frequencies >60 Hz if the
    excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron
    synapses may promote the generation of high-frequency oscillations observed in
    the dentate gyrusin vivo. '
acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft
  (SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B).
  We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading
  this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction
  and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical
  assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
- first_name: Imre
  full_name: Vida, Imre
  last_name: Vida
- first_name: Michael
  full_name: Frotscher, Michael
  last_name: Frotscher
- first_name: Jörg
  full_name: Geiger, Jörg
  last_name: Geiger
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory
    synapses in a dentate gyrus interneuron network. <i>Journal of Neuroscience</i>.
    2001;21(8):2687-2698. doi:<a href="https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001">10.1523/JNEUROSCI.21-08-02687.2001</a>
  apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., &#38; Jonas, P. M. (2001).
    Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
    <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001">https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001</a>
  chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M
    Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron
    Network.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2001. <a href="https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001">https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001</a>.
  ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling
    at inhibitory synapses in a dentate gyrus interneuron network.,” <i>Journal of
    Neuroscience</i>, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001.
  ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at
    inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
    21(8), 2687–2698.
  mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate
    Gyrus Interneuron Network.” <i>Journal of Neuroscience</i>, vol. 21, no. 8, Society
    for Neuroscience, 2001, pp. 2687–98, doi:<a href="https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001">10.1523/JNEUROSCI.21-08-02687.2001</a>.
  short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience
    21 (2001) 2687–2698.
date_created: 2018-12-11T12:03:37Z
date_published: 2001-04-15T00:00:00Z
date_updated: 2023-05-15T13:47:04Z
day: '15'
doi: 10.1523/JNEUROSCI.21-08-02687.2001
extern: '1'
external_id:
  pmid:
  - '11306622'
intvolume: '        21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/
month: '04'
oa: 1
oa_version: Published Version
page: 2687 - 2698
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2893'
quality_controlled: '1'
status: public
title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...