---
res:
  bibo_abstract:
  - 'Information in neuronal networks is thought to be represented by the rate of
    discharge and the temporal relationship between the discharging neurons. The discharge
    frequency of neurons is affected by their afferents and intrinsic properties,
    and shows great individual variability. The temporal coordination of neurons is
    greatly facilitated by network oscillations. In the hippocampus, population synchrony
    fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase
    almost 10-fold during sharp wave bursts. Despite these large changes in excitability
    in the sub-second scale, longer-term (minute-scale) firing rates of individual
    neurons are relatively constant in an unchanging environment. As a result, mean
    hippocampal output remains stable over time. To understand the mechanisms responsible
    for this homeostasis, we address the following issues: (i) Can firing rates of
    single cells be modified? (ii) Once modified, what mechanism(s) can maintain the
    changes? We show that firing rates of hippocampal pyramidal cells can be altered
    in a novel environment and by Hebbian pairing of physiological input patterns
    with postsynaptic burst discharge. We also illustrate a competition between single
    spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold)
    inputs decrease the ability of strong (''teaching'') inputs to induce a burst
    discharge, we propose that the single spike versus burst competition presents
    a homeostatic regulatory mechanism to maintain synaptic strength and, consequently,
    firing rate in pyramidal cells.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: György
      foaf_name: Buzsáki, György
      foaf_surname: Buzsáki
  - foaf_Person:
      foaf_givenName: Jozsef L
      foaf_name: Csicsvari, Jozsef L
      foaf_surname: Csicsvari
      foaf_workInfoHomepage: http://www.librecat.org/personId=3FA14672-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-5193-4036
  - foaf_Person:
      foaf_givenName: George
      foaf_name: Dragoi, George
      foaf_surname: Dragoi
  - foaf_Person:
      foaf_givenName: Kenneth
      foaf_name: Harris, Kenneth
      foaf_surname: Harris
  - foaf_Person:
      foaf_givenName: D.
      foaf_name: Henze, D.
      foaf_surname: Henze
  - foaf_Person:
      foaf_givenName: Hajima
      foaf_name: Hirase, Hajima
      foaf_surname: Hirase
  bibo_doi: 10.1093/cercor/12.9.893
  bibo_issue: '9'
  bibo_volume: 12
  dct_date: 2002^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1047-3211
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Homeostatic maintenance of neuronal excitability by burst discharges
    in vivo@
  fabio_hasPubmedId: '12183388'
...