Homeostatic maintenance of neuronal excitability by burst discharges in vivo

article Homeostatic maintenance of neuronal excitability by burst discharges in vivo published yes György Buzsáki author Jozsef L Csicsvari author 3FA14672-F248-11E8-B48F-1D18A9856A870000-0002-5193-4036 George Dragoi author Kenneth Harris author D. Henze author Hajima Hirase author Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by their afferents and intrinsic properties, and shows great individual variability. The temporal coordination of neurons is greatly facilitated by network oscillations. In the hippocampus, population synchrony fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase almost 10-fold during sharp wave bursts. Despite these large changes in excitability in the sub-second scale, longer-term (minute-scale) firing rates of individual neurons are relatively constant in an unchanging environment. As a result, mean hippocampal output remains stable over time. To understand the mechanisms responsible for this homeostasis, we address the following issues: (i) Can firing rates of single cells be modified? (ii) Once modified, what mechanism(s) can maintain the changes? We show that firing rates of hippocampal pyramidal cells can be altered in a novel environment and by Hebbian pairing of physiological input patterns with postsynaptic burst discharge. We also illustrate a competition between single spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold) inputs decrease the ability of strong ('teaching') inputs to induce a burst discharge, we propose that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells. Oxford University Press2002 eng Cerebral Cortex 1047-3211 1218338810.1093/cercor/12.9.893 129893 - 899 yes G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase, “Homeostatic maintenance of neuronal excitability by burst discharges in vivo,” Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899, 2002. G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral Cortex 12 (2002) 893–899. Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002, pp. 893–99, doi:<a href="https://doi.org/10.1093/cercor/12.9.893">10.1093/cercor/12.9.893</a>. Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase, H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. Oxford University Press. <a href="https://doi.org/10.1093/cercor/12.9.893">https://doi.org/10.1093/cercor/12.9.893</a> Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D. Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002. <a href="https://doi.org/10.1093/cercor/12.9.893">https://doi.org/10.1093/cercor/12.9.893</a>. Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 2002;12(9):893-899. doi:<a href="https://doi.org/10.1093/cercor/12.9.893">10.1093/cercor/12.9.893</a> Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex. 12(9), 893–899. 35332018-12-11T12:03:50Z2023-07-17T07:27:12Z