---
_id: '3533'
abstract:
- lang: eng
  text: 'Information in neuronal networks is thought to be represented by the rate
    of discharge and the temporal relationship between the discharging neurons. The
    discharge frequency of neurons is affected by their afferents and intrinsic properties,
    and shows great individual variability. The temporal coordination of neurons is
    greatly facilitated by network oscillations. In the hippocampus, population synchrony
    fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase
    almost 10-fold during sharp wave bursts. Despite these large changes in excitability
    in the sub-second scale, longer-term (minute-scale) firing rates of individual
    neurons are relatively constant in an unchanging environment. As a result, mean
    hippocampal output remains stable over time. To understand the mechanisms responsible
    for this homeostasis, we address the following issues: (i) Can firing rates of
    single cells be modified? (ii) Once modified, what mechanism(s) can maintain the
    changes? We show that firing rates of hippocampal pyramidal cells can be altered
    in a novel environment and by Hebbian pairing of physiological input patterns
    with postsynaptic burst discharge. We also illustrate a competition between single
    spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold)
    inputs decrease the ability of strong (''teaching'') inputs to induce a burst
    discharge, we propose that the single spike versus burst competition presents
    a homeostatic regulatory mechanism to maintain synaptic strength and, consequently,
    firing rate in pyramidal cells.'
article_processing_charge: No
article_type: original
author:
- first_name: György
  full_name: Buzsáki, György
  last_name: Buzsáki
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: George
  full_name: Dragoi, George
  last_name: Dragoi
- first_name: Kenneth
  full_name: Harris, Kenneth
  last_name: Harris
- first_name: D.
  full_name: Henze, D.
  last_name: Henze
- first_name: Hajima
  full_name: Hirase, Hajima
  last_name: Hirase
citation:
  ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic
    maintenance of neuronal excitability by burst discharges in vivo. <i>Cerebral
    Cortex</i>. 2002;12(9):893-899. doi:<a href="https://doi.org/10.1093/cercor/12.9.893">10.1093/cercor/12.9.893</a>
  apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., &#38; Hirase,
    H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges
    in vivo. <i>Cerebral Cortex</i>. Oxford University Press. <a href="https://doi.org/10.1093/cercor/12.9.893">https://doi.org/10.1093/cercor/12.9.893</a>
  chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D.
    Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by
    Burst Discharges in Vivo.” <i>Cerebral Cortex</i>. Oxford University Press, 2002.
    <a href="https://doi.org/10.1093/cercor/12.9.893">https://doi.org/10.1093/cercor/12.9.893</a>.
  ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase,
    “Homeostatic maintenance of neuronal excitability by burst discharges in vivo,”
    <i>Cerebral Cortex</i>, vol. 12, no. 9. Oxford University Press, pp. 893–899,
    2002.
  ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic
    maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex.
    12(9), 893–899.
  mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by
    Burst Discharges in Vivo.” <i>Cerebral Cortex</i>, vol. 12, no. 9, Oxford University
    Press, 2002, pp. 893–99, doi:<a href="https://doi.org/10.1093/cercor/12.9.893">10.1093/cercor/12.9.893</a>.
  short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral
    Cortex 12 (2002) 893–899.
date_created: 2018-12-11T12:03:50Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-17T07:27:12Z
day: '01'
doi: 10.1093/cercor/12.9.893
extern: '1'
external_id:
  pmid:
  - '12183388'
intvolume: '        12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 893 - 899
pmid: 1
publication: Cerebral Cortex
publication_identifier:
  issn:
  - 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '2851'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...