---
_id: '3539'
abstract:
- lang: eng
  text: In the hippocampus, spatial representation of the environment has been suggested
    to be coded by either the firing rate of pyramidal cell assemblies or the relative
    timing of the action potentials during the theta EEG cycle. Here, we used a behavioural
    `space clamp' method, which involved the confinement of the actively running animal
    in a defined position in space (running wheel) to examine how `spatial' and other
    inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons.
    Nineteen per cent of the recorded CA1 pyramidal cells were selectively active
    while the rat was running in the wheel in a given direction ('wheel' cells). Spatial
    rotation of the apparatus showed that selective discharge of pyramidal cells in
    the wheel was under the combined influence of distal and apparatus cues. During
    steady running, both discharge rate and theta phase were constant. Rotation of
    the wheel apparatus resulted in a shift of both firing rate and preferred theta
    phase. The discharge frequency of `wheel' cells increased threefold (on average)
    with increasing running velocity. In contrast, change in running speed had relatively
    little effect on the theta phase-related discharge of `wheel' cells. Our findings
    indicate that mechanisms that regulate rate and phase of spikes are overlapping
    but not necessarily identical.
acknowledgement: 'We thank M. Recce for his comments on the manuscript. This work
  wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.),
  the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) '
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
  full_name: Hirase, Hajima
  last_name: Hirase
- first_name: András
  full_name: Czurkó, András
  last_name: Czurkó
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: György
  full_name: Buzsáki, György
  last_name: Buzsáki
citation:
  ama: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding
    by hippocampal pyramidal neurons during ‘space clamping.’ <i>European Journal
    of Neuroscience</i>. 1999;11(12):4373-4380. doi:<a href="https://doi.org/10.1046/j.1460-9568.1999.00853.x">10.1046/j.1460-9568.1999.00853.x</a>
  apa: Hirase, H., Czurkó, A., Csicsvari, J. L., &#38; Buzsáki, G. (1999). Firing
    rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’
    <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href="https://doi.org/10.1046/j.1460-9568.1999.00853.x">https://doi.org/10.1046/j.1460-9568.1999.00853.x</a>
  chicago: Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki.
    “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space
    Clamping.’” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 1999. <a
    href="https://doi.org/10.1046/j.1460-9568.1999.00853.x">https://doi.org/10.1046/j.1460-9568.1999.00853.x</a>.
  ieee: H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase
    coding by hippocampal pyramidal neurons during ‘space clamping,’” <i>European
    Journal of Neuroscience</i>, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380,
    1999.
  ista: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase
    coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal
    of Neuroscience. 11(12), 4373–4380.
  mla: Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal
    Neurons during ‘Space Clamping.’” <i>European Journal of Neuroscience</i>, vol.
    11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:<a href="https://doi.org/10.1046/j.1460-9568.1999.00853.x">10.1046/j.1460-9568.1999.00853.x</a>.
  short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
    11 (1999) 4373–4380.
date_created: 2018-12-11T12:03:51Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:45:36Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00853.x
extern: '1'
external_id:
  pmid:
  - '10594664 '
intvolume: '        11'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 4373 - 4380
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
  issn:
  - 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2845'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rate and theta-phase coding by hippocampal pyramidal neurons during
  ‘space clamping’
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...