---
_id: '3544'
abstract:
- lang: eng
text: In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced
synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies
movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly
and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate
rhythms might also emerge acutely from disrupted dopamine transmission. The neural
basis of these abnormal beta oscillations is unclear, and how they might compromise
information processing, or how they arise, is unknown. Using a 6-hydroxydopamine-lesioned
rodent model of PD, we demonstrate that beta oscillations are inappropriately
exaggerated, compared with controls, in a brain-state-dependent manner after chronic
dopamine loss. Exaggerated beta oscillations are expressed at the levels of single
neurons and small neuronal ensembles, and are focally present and spatially distributed
within STN. They are also expressed in synchronous population activities, as evinced
by oscillatory local field potentials, in STN and cortex. Excessively synchronized
beta oscillations reduce the information coding capacity of STN neuronal ensembles,
which may contribute to parkinsonian motor impairment. Acute disruption of dopamine
transmission in control animals with antagonists of D-1/D-2 receptors did not
exaggerate STN or cortical beta oscillations. Moreover, beta oscillations were
not exaggerated until several days after 6-hydroxydopamine injections. Thus, contrary
to predictions, abnormally amplified beta oscillations in cortico-STN circuits
do not result simply from an acute absence of dopamine receptor stimulation, but
are instead delayed sequelae of chronic dopamine depletion. Targeting the plastic
processes underlying the delayed emergence of pathological beta oscillations after
continuing dopaminergic dysfunction may offer considerable therapeutic promise.
author:
- first_name: Nicolas
full_name: Mallet,Nicolas
last_name: Mallet
- first_name: Alek
full_name: Pogosyan,Alek
last_name: Pogosyan
- first_name: Andrew
full_name: Sharott,Andrew
last_name: Sharott
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: John
full_name: Bolam, John Paul
last_name: Bolam
- first_name: Peter
full_name: Brown,Peter
last_name: Brown
- first_name: Peter
full_name: Magill,Peter J
last_name: Magill
citation:
ama: Mallet N, Pogosyan A, Sharott A, et al. Disrupted dopamine transmission and
the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral
cortex. Journal of Neuroscience. 2008;28(18):4795-4806. doi:10.1523/JNEUROSCI.0123-08.2008
apa: Mallet, N., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., Brown,
P., & Magill, P. (2008). Disrupted dopamine transmission and the emergence
of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0123-08.2008
chicago: Mallet, Nicolas, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John
Bolam, Peter Brown, and Peter Magill. “Disrupted Dopamine Transmission and the
Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral
Cortex.” Journal of Neuroscience. Society for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.0123-08.2008.
ieee: N. Mallet et al., “Disrupted dopamine transmission and the emergence
of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex,”
Journal of Neuroscience, vol. 28, no. 18. Society for Neuroscience, pp.
4795–4806, 2008.
ista: Mallet N, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P, Magill P.
2008. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. 28(18), 4795–4806.
mla: Mallet, Nicolas, et al. “Disrupted Dopamine Transmission and the Emergence
of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex.”
Journal of Neuroscience, vol. 28, no. 18, Society for Neuroscience, 2008,
pp. 4795–806, doi:10.1523/JNEUROSCI.0123-08.2008.
short: N. Mallet, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, P.
Magill, Journal of Neuroscience 28 (2008) 4795–4806.
date_created: 2018-12-11T12:03:53Z
date_published: 2008-04-30T00:00:00Z
date_updated: 2021-01-12T07:44:12Z
day: '30'
doi: 10.1523/JNEUROSCI.0123-08.2008
extern: 1
intvolume: ' 28'
issue: '18'
month: '04'
page: 4795 - 4806
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2842'
quality_controlled: 0
status: public
title: Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
in subthalamic nucleus and cerebral cortex
type: journal_article
volume: 28
year: '2008'
...