---
_id: '3621'
abstract:
- lang: eng
  text: In 1991, Barton and Turelli developed recursions to describe the evolution
    of multilocus systems under arbitrary forms of selection. This article generalizes
    their approach to allow for arbitrary modes of inheritance, including diploidy,
    polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The
    framework is also extended to allow for other deterministic evolutionary forces,
    including migration and mutation. Exact recursions that fully describe the state
    of the population are presented; these are implemented in a computer algebra package
    (available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality
    of our framework, it can describe evolutionary dynamics exactly by just two equations.
    These recursions can be further simplified using a "quasi-linkage equilibrium"
    (QLE) approximation. We illustrate the methods by finding the effect of natural
    selection, sexual selection, mutation, and migration on the genetic composition
    of a population.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
  full_name: Kirkpatrick, Mark
  last_name: Kirkpatrick
- first_name: Toby
  full_name: Johnson, Toby
  last_name: Johnson
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution.
    <i>Genetics</i>. 2002;161(4):1727-1750. doi:<a href="https://doi.org/10.1093/genetics/161.4.1727">10.1093/genetics/161.4.1727</a>
  apa: Kirkpatrick, M., Johnson, T., &#38; Barton, N. H. (2002). General models of
    multilocus evolution. <i>Genetics</i>. Genetics Society of America. <a href="https://doi.org/10.1093/genetics/161.4.1727">https://doi.org/10.1093/genetics/161.4.1727</a>
  chicago: Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models
    of Multilocus Evolution.” <i>Genetics</i>. Genetics Society of America, 2002.
    <a href="https://doi.org/10.1093/genetics/161.4.1727">https://doi.org/10.1093/genetics/161.4.1727</a>.
  ieee: M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus
    evolution,” <i>Genetics</i>, vol. 161, no. 4. Genetics Society of America, pp.
    1727–1750, 2002.
  ista: Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution.
    Genetics. 161(4), 1727–1750.
  mla: Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” <i>Genetics</i>,
    vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:<a href="https://doi.org/10.1093/genetics/161.4.1727">10.1093/genetics/161.4.1727</a>.
  short: M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750.
date_created: 2018-12-11T12:04:17Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-11T13:20:26Z
day: '01'
doi: 10.1093/genetics/161.4.1727
extern: '1'
external_id:
  pmid:
  - '12196414'
intvolume: '       161'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/
month: '08'
oa: 1
oa_version: Published Version
page: 1727 - 1750
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2762'
quality_controlled: '1'
scopus_import: '1'
status: public
title: General models of multilocus evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...