---
res:
  bibo_abstract:
  - 'The state of a diploid population segregating for two alleles at each of n loci
    is described by 22(n) genotype frequencies, or equivalently, by allele frequencies
    and by multilocus moments or cumulants of various orders. These measures of linkage
    disequilibrium cannot usually be determined, both because one cannot tell whether
    a gene came from the maternal or paternal gamete, and because such a large number
    of parameters cannot be estimated even from large samples. Simplifying assumptions
    must therefore be made. This paper sets out methods for estimating multilocus
    genotype frequencies which are appropriate for unlinked neutral loci, and for
    populations that are ultimately derived by mixing of two source populations. In
    such a hybrid population, all multilocus associations depend primarily on the
    number of loci involved that derive from the maternal genome, and the number derived
    from the paternal genome Allele frequencies may differ across loci, and the contribution
    of each locus to multilocus associations may be scaled by the difference in allele
    frequency between source populations for that locus (δp ≤ 1). For example, the
    cumulant describing the association between genes i, j, k from the maternal genome,
    and genes i, l from the paternal genome is K(tJ,k,iλ*), = δp(i)/2 δp(J) δp(k)
    δp(l) κ3,2. The state of the population is described by n allele frequencies;
    n divergences, δp; and by a symmetric matrix of cumulants, κ(J,K) (J = 0 ,...,
    n, K = 0 ,..., n). Expressions for these cumulants under short- and long-range
    migration are given. Two methods for estimating the cumulants are described: a
    simple method based on multivariate moments, and a maximum likelihood procedure,
    which uses the Metropolis algorithm. Both methods perform well when tested against
    simulations with two or four loci.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  bibo_doi: 10.1046/j.1365-2540.2000.00683.x
  bibo_issue: '3'
  bibo_volume: 84
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0018-067X
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Estimating multilocus linkage disequilibria@
  fabio_hasPubmedId: '10762407'
...