---
res:
  bibo_abstract:
  - 'A general representation of multilocus selection is extended to allow recombination
    to depend on genotype. The equations simplify if modifier alleles have small effects
    on recombination. The evolution of such modifiers only depends on how they alter
    recombination between the selected loci, and does not involve dominance in modifier
    effects. The net selection on modifiers can be found explicitly if epistasis is
    weak relative to recombination. This analysis shows that recombination can be
    favoured in two ways: because it impedes the response to epistasis which fluctuates
    in sign, or because it facilitates the response to directional selection. The
    first mechanism is implausible, because epistasis must change sign over periods
    of a few generations: faster or slower fluctuations favour reduced recombination.
    The second mechanism requires weak negative epistasis between favourable alleles,
    which may either be increasing, or held in check by mutation. The selection (si)
    on recombination modifiers depends on the reduction in additive variance of log
    (fitness) due to linkage disequilibria (υ1 < 0), and on non-additive variance
    in log (fitness) (V′2, V′3,.. epistasis between 2, 3.. loci). For unlinked loci
    and pairwise epistasis, si = − (υ1 + 4V2/3)δr, where δr is the average increase
    in recombination caused by the modifier. The approximations are checked against
    exact calculations for three loci, and against Charlesworth''s analyses of mutation/selection
    balance (1990), and directional selection (1993). The analysis demonstrates a
    general relation between selection on recombination and observable components
    of fitness variation, which is open to experimental test.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  bibo_doi: 10.1017/S0016672300033140
  bibo_issue: '2'
  bibo_volume: 65
  dct_date: 1995^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0016-6723
  dct_language: eng
  dct_publisher: Cambridge University Press@
  dct_title: A general model for the evolution of recombination@
  fabio_hasPubmedId: '7605514'
...