---
_id: '3639'
abstract:
- lang: eng
  text: 'A general representation of multilocus selection is extended to allow recombination
    to depend on genotype. The equations simplify if modifier alleles have small effects
    on recombination. The evolution of such modifiers only depends on how they alter
    recombination between the selected loci, and does not involve dominance in modifier
    effects. The net selection on modifiers can be found explicitly if epistasis is
    weak relative to recombination. This analysis shows that recombination can be
    favoured in two ways: because it impedes the response to epistasis which fluctuates
    in sign, or because it facilitates the response to directional selection. The
    first mechanism is implausible, because epistasis must change sign over periods
    of a few generations: faster or slower fluctuations favour reduced recombination.
    The second mechanism requires weak negative epistasis between favourable alleles,
    which may either be increasing, or held in check by mutation. The selection (si)
    on recombination modifiers depends on the reduction in additive variance of log
    (fitness) due to linkage disequilibria (υ1 < 0), and on non-additive variance
    in log (fitness) (V′2, V′3,.. epistasis between 2, 3.. loci). For unlinked loci
    and pairwise epistasis, si = − (υ1 + 4V2/3)δr, where δr is the average increase
    in recombination caused by the modifier. The approximations are checked against
    exact calculations for three loci, and against Charlesworth''s analyses of mutation/selection
    balance (1990), and directional selection (1993). The analysis demonstrates a
    general relation between selection on recombination and observable components
    of fitness variation, which is open to experimental test.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. A general model for the evolution of recombination. <i>Genetical
    Research</i>. 1995;65(2):123-144. doi:<a href="https://doi.org/10.1017/S0016672300033140">10.1017/S0016672300033140</a>
  apa: Barton, N. H. (1995). A general model for the evolution of recombination. <i>Genetical
    Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672300033140">https://doi.org/10.1017/S0016672300033140</a>
  chicago: Barton, Nicholas H. “A General Model for the Evolution of Recombination.”
    <i>Genetical Research</i>. Cambridge University Press, 1995. <a href="https://doi.org/10.1017/S0016672300033140">https://doi.org/10.1017/S0016672300033140</a>.
  ieee: N. H. Barton, “A general model for the evolution of recombination,” <i>Genetical
    Research</i>, vol. 65, no. 2. Cambridge University Press, pp. 123–144, 1995.
  ista: Barton NH. 1995. A general model for the evolution of recombination. Genetical
    Research. 65(2), 123–144.
  mla: Barton, Nicholas H. “A General Model for the Evolution of Recombination.” <i>Genetical
    Research</i>, vol. 65, no. 2, Cambridge University Press, 1995, pp. 123–44, doi:<a
    href="https://doi.org/10.1017/S0016672300033140">10.1017/S0016672300033140</a>.
  short: N.H. Barton, Genetical Research 65 (1995) 123–144.
date_created: 2018-12-11T12:04:23Z
date_published: 1995-04-01T00:00:00Z
date_updated: 2022-06-24T11:54:10Z
day: '01'
doi: 10.1017/S0016672300033140
extern: '1'
external_id:
  pmid:
  - '7605514'
intvolume: '        65'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/general-model-for-the-evolution-of-recombination/8CBDDF2DC779CF4B6AE9B461B80BB4AE
month: '04'
oa_version: None
page: 123 - 144
pmid: 1
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2744'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A general model for the evolution of recombination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 65
year: '1995'
...